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6jle

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Current revision (10:38, 27 March 2024) (edit) (undo)
 
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<StructureSection load='6jle' size='340' side='right'caption='[[6jle]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='6jle' size='340' side='right'caption='[[6jle]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6jle]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JLE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6jle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JLE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jle OCA], [http://pdbe.org/6jle PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jle RCSB], [http://www.ebi.ac.uk/pdbsum/6jle PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jle ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jle OCA], [https://pdbe.org/6jle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jle RCSB], [https://www.ebi.ac.uk/pdbsum/6jle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jle ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/MYO3A_HUMAN MYO3A_HUMAN]] Autosomal recessive non-syndromic sensorineural deafness type DFNB. The disease is caused by mutations affecting the gene represented in this entry.
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MORN4_MOUSE MORN4_MOUSE]] Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.<ref>PMID:22496551</ref> [[http://www.uniprot.org/uniprot/MYO3A_HUMAN MYO3A_HUMAN]] Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (PubMed:12032315). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (By similarity).[UniProtKB:Q8K3H5]<ref>PMID:12032315</ref>
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[https://www.uniprot.org/uniprot/MORN4_MOUSE MORN4_MOUSE] Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.<ref>PMID:22496551</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Tandem repeats are basic building blocks for constructing proteins with diverse structures and functions. Compared with extensively studied alpha-helix-based tandem repeats such as ankyrin, tetratricopeptide, armadillo, and HEAT repeat proteins, relatively little is known about tandem repeat proteins formed by beta hairpins. In this study, we discovered that the MORN repeats from MORN4 function as a protein binding module specifically recognizing a tail cargo binding region from Myo3a. The structure of the MORN4/Myo3a complex shows that MORN4 forms an extended single-layered beta-sheet structure and uses a U-shaped groove to bind to the Myo3a tail with high affinity and specificity. Sequence and structural analyses further elucidated the unique sequence features for folding and target binding of MORN repeats. Our work establishes that the beta-hairpin-based MORN repeats are protein-protein interaction modules.
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Structure of the MORN4/Myo3a Tail Complex Reveals MORN Repeats as Protein Binding Modules.,Li J, Liu H, Raval MH, Wan J, Yengo CM, Liu W, Zhang M Structure. 2019 Jun 28. pii: S0969-2126(19)30203-5. doi:, 10.1016/j.str.2019.06.004. PMID:31279628<ref>PMID:31279628</ref>
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==See Also==
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*[[Myosin 3D Structures|Myosin 3D Structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6jle" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Mus musculus]]
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[[Category: Li, J]]
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[[Category: Li J]]
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[[Category: Liu, H]]
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[[Category: Liu H]]
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[[Category: Liu, W]]
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[[Category: Liu W]]
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[[Category: Raval, M H]]
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[[Category: Raval MH]]
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[[Category: Wan, J]]
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[[Category: Wan J]]
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[[Category: Yengo, C M]]
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[[Category: Yengo CM]]
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[[Category: Zhang, M]]
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[[Category: Zhang M]]
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[[Category: Motor protein]]
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[[Category: Protein binding]]
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[[Category: Protein transport]]
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Current revision

Crystal structure of MORN4/Myo3a complex

PDB ID 6jle

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