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6jt2

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==Structure of human soluble guanylate cyclase in the NO activated state==
==Structure of human soluble guanylate cyclase in the NO activated state==
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<StructureSection load='6jt2' size='340' side='right'caption='[[6jt2]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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<SX load='6jt2' size='340' side='right' viewer='molstar' caption='[[6jt2]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6jt2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JT2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6jt2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JT2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JT2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GUCY1A1, GUC1A3, GUCSA3, GUCY1A3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GUCY1B1, GUC1B3, GUCSB3, GUCY1B3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G2P:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>G2P</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Guanylate_cyclase Guanylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.2 4.6.1.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jt2 OCA], [https://pdbe.org/6jt2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jt2 RCSB], [https://www.ebi.ac.uk/pdbsum/6jt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jt2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jt2 OCA], [http://pdbe.org/6jt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jt2 RCSB], [http://www.ebi.ac.uk/pdbsum/6jt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jt2 ProSAT]</span></td></tr>
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</table>
</table>
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== Disease ==
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== Function ==
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[[http://www.uniprot.org/uniprot/GCYA1_HUMAN GCYA1_HUMAN]] Moyamoya disease with early-onset achalasia. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/GCYB1_HUMAN GCYB1_HUMAN]
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==See Also==
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*[[Guanylate cyclase 3D structures|Guanylate cyclase 3D structures]]
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Guanylate cyclase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, L]]
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[[Category: Chen L]]
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[[Category: Kang, Y]]
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[[Category: Kang Y]]
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[[Category: Liu, R]]
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[[Category: Liu R]]
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[[Category: Wu, J X]]
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[[Category: Wu J-X]]
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[[Category: Signaling protein]]
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[[Category: Soluble guanylate cyclase]]
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Current revision

Structure of human soluble guanylate cyclase in the NO activated state

6jt2, resolution 3.80Å

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