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6k7y
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits== | |
| + | <StructureSection load='6k7y' size='340' side='right'caption='[[6k7y]], [[Resolution|resolution]] 3.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6k7y]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K7Y FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=PLX:(9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL'>PLX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k7y OCA], [https://pdbe.org/6k7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k7y RCSB], [https://www.ebi.ac.uk/pdbsum/6k7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k7y ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MICU2_HUMAN MICU2_HUMAN] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).<ref>PMID:24503055</ref> <ref>PMID:24560927</ref> <ref>PMID:26387864</ref> <ref>PMID:26903221</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Calcium uptake protein 3D structures|Calcium uptake protein 3D structures]] | |
| - | + | *[[Mitochondrial calcium uniporter|Mitochondrial calcium uniporter]] | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yang M]] | ||
| + | [[Category: Zhou H]] | ||
| + | [[Category: Zhuo W]] | ||
Current revision
Intact human mitochondrial calcium uniporter complex with MICU1/MICU2 subunits
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Categories: Homo sapiens | Large Structures | Yang M | Zhou H | Zhuo W
