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6l49
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==H3-CA-H3 tri-nucleosome with the 22 base-pair linker DNA== | |
| + | <SX load='6l49' size='340' side='right' viewer='molstar' caption='[[6l49]], [[Resolution|resolution]] 18.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6l49]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L49 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 18.9Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l49 OCA], [https://pdbe.org/6l49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l49 RCSB], [https://www.ebi.ac.uk/pdbsum/6l49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l49 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Centromere protein 3D structure|Centromere protein 3D structure]] | |
| - | + | *[[Histone 3D structures|Histone 3D structures]] | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Ho C-H]] | ||
| + | [[Category: Kurumizaka H]] | ||
| + | [[Category: Matsunami H]] | ||
| + | [[Category: Ohi M]] | ||
| + | [[Category: Tachiwana H]] | ||
| + | [[Category: Takizawa Y]] | ||
| + | [[Category: Wolf M]] | ||
Current revision
H3-CA-H3 tri-nucleosome with the 22 base-pair linker DNA
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