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6m49
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.== | |
| - | + | <StructureSection load='6m49' size='340' side='right'caption='[[6m49]], [[Resolution|resolution]] 3.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6m49]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M49 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC3:25-HYDROXYCHOLESTEROL'>HC3</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m49 OCA], [https://pdbe.org/6m49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m49 RCSB], [https://www.ebi.ac.uk/pdbsum/6m49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m49 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/INSI2_HUMAN INSI2_HUMAN] Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.<ref>PMID:12242332</ref> <ref>PMID:16606821</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brown AJ]] | ||
| + | [[Category: Cao P]] | ||
| + | [[Category: Coates HW]] | ||
| + | [[Category: Du X]] | ||
| + | [[Category: Gao S]] | ||
| + | [[Category: Gong X]] | ||
| + | [[Category: Lei J]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Liu X]] | ||
| + | [[Category: Qian H]] | ||
| + | [[Category: Song W]] | ||
| + | [[Category: Sui J]] | ||
| + | [[Category: Yan C]] | ||
| + | [[Category: Yan N]] | ||
| + | [[Category: Yan R]] | ||
| + | [[Category: Yang H]] | ||
| + | [[Category: Zhao X]] | ||
| + | [[Category: Zhou Q]] | ||
Current revision
cryo-EM structure of Scap/Insig complex in the present of 25-hydroxyl cholesterol.
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