1rd8

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[[Image:1rd8.gif|left|200px]]
[[Image:1rd8.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1rd8 |SIZE=350|CAPTION= <scene name='initialview01'>1rd8</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1rd8", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= Hemagglutinin ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11320 Influenza A virus])
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-->
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|DOMAIN=
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{{STRUCTURE_1rd8| PDB=1rd8 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rd8 OCA], [http://www.ebi.ac.uk/pdbsum/1rd8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rd8 RCSB]</span>
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}}
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'''Crystal Sructure of the 1918 Human H1 Hemagglutinin Precursor (HA0)'''
'''Crystal Sructure of the 1918 Human H1 Hemagglutinin Precursor (HA0)'''
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[[Category: Taubenberger, J K.]]
[[Category: Taubenberger, J K.]]
[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: membrane-fusion precursor]]
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[[Category: Membrane-fusion precursor]]
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[[Category: virus/viral protein]]
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[[Category: Virus/viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:21:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:26:27 2008''
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Revision as of 04:21, 3 May 2008

Image:1rd8.gif

Template:STRUCTURE 1rd8

Crystal Sructure of the 1918 Human H1 Hemagglutinin Precursor (HA0)


Overview

The 1918 "Spanish" influenza pandemic represents the largest recorded outbreak of any infectious disease. The crystal structure of the uncleaved precursor of the major surface antigen of the extinct 1918 virus was determined at 3.0 angstrom resolution after reassembly of the hemagglutinin gene from viral RNA fragments preserved in 1918 formalin-fixed lung tissues. A narrow avian-like receptor-binding site, two previously unobserved histidine patches, and a less exposed surface loop at the cleavage site that activates viral membrane fusion reveal structural features primarily found in avian viruses, which may have contributed to the extraordinarily high infectivity and mortality rates observed during 1918.

About this Structure

1RD8 is a Protein complex structure of sequences from Influenza a virus. The following page contains interesting information on the relation of 1RD8 with [Hemagglutinin]. Full crystallographic information is available from OCA.

Reference

Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus., Stevens J, Corper AL, Basler CF, Taubenberger JK, Palese P, Wilson IA, Science. 2004 Mar 19;303(5665):1866-70. Epub 2004 Feb 5. PMID:14764887 Page seeded by OCA on Sat May 3 07:21:24 2008

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