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1akg
From Proteopedia
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| - | [[Image:1akg.png|left|200px]] | ||
| - | + | ==ALPHA-CONOTOXIN PNIB FROM CONUS PENNACEUS== | |
| - | + | <StructureSection load='1akg' size='340' side='right'caption='[[1akg]], [[Resolution|resolution]] 1.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1akg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_pennaceus Conus pennaceus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AKG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AKG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1akg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akg OCA], [https://pdbe.org/1akg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1akg RCSB], [https://www.ebi.ac.uk/pdbsum/1akg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1akg ProSAT]</span></td></tr> |
| - | [[1akg]] is a 1 chain structure with sequence from [ | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CA1B_CONPE CA1B_CONPE] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian nAChRs (alpha-7 > alpha-3/beta-2).<ref>PMID:10545176</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Conus pennaceus]] | [[Category: Conus pennaceus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hu S-H]] |
| - | [[Category: | + | [[Category: Martin JL]] |
| - | + | ||
Current revision
ALPHA-CONOTOXIN PNIB FROM CONUS PENNACEUS
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