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1fj8

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{{Seed}}
 
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[[Image:1fj8.png|left|200px]]
 
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==THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN==
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The line below this paragraph, containing "STRUCTURE_1fj8", creates the "Structure Box" on the page.
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<StructureSection load='1fj8' size='340' side='right'caption='[[1fj8]], [[Resolution|resolution]] 2.27&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fj8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FJ8 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.27&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CER:(2S,+3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE'>CER</scene></td></tr>
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{{STRUCTURE_1fj8| PDB=1fj8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fj8 OCA], [https://pdbe.org/1fj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fj8 RCSB], [https://www.ebi.ac.uk/pdbsum/1fj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fj8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FABB_ECOLI FABB_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/1fj8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fj8 ConSurf].
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<div style="clear:both"></div>
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===THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN===
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==See Also==
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*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11050088}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11050088 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11050088}}
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==About this Structure==
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1FJ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FJ8 OCA].
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==Reference==
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Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism., Price AC, Choi KH, Heath RJ, Li Z, White SW, Rock CO, J Biol Chem. 2001 Mar 2;276(9):6551-9. Epub 2000 Oct 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11050088 11050088]
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[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Choi, K.]]
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[[Category: Choi K]]
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[[Category: Heath, R J.]]
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[[Category: Heath RJ]]
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[[Category: Li, Z.]]
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[[Category: Li Z]]
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[[Category: Price, A C.]]
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[[Category: Price AC]]
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[[Category: Rock, C O.]]
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[[Category: Rock CO]]
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[[Category: White, S W.]]
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[[Category: White SW]]
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[[Category: Cerulenin]]
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[[Category: Condensing enzyme]]
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[[Category: Drug design]]
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[[Category: Fatty acid elongation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:21:14 2008''
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Current revision

THE STRUCTURE OF BETA-KETOACYL-[ACYL CARRIER PROTEIN] SYNTHASE I IN COMPLEX WITH CERULENIN, IMPLICATIONS FOR DRUG DESIGN

PDB ID 1fj8

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