1fnx
From Proteopedia
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| - | [[Image:1fnx.gif|left|200px]]<br /><applet load="1fnx" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1fnx" /> | ||
| - | '''SOLUTION STRUCTURE OF THE HUC RBD1-RBD2 COMPLEXED WITH THE AU-RICH ELEMENT'''<br /> | ||
| - | == | + | ==SOLUTION STRUCTURE OF THE HUC RBD1-RBD2 COMPLEXED WITH THE AU-RICH ELEMENT== |
| - | + | <StructureSection load='1fnx' size='340' side='right'caption='[[1fnx]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1fnx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FNX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FNX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fnx OCA], [https://pdbe.org/1fnx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fnx RCSB], [https://www.ebi.ac.uk/pdbsum/1fnx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fnx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ELAV3_MOUSE ELAV3_MOUSE] Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance.<ref>PMID:9016658</ref> <ref>PMID:10734193</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/1fnx_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fnx ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | + | [[Category: Hirao M]] | |
| - | [[Category: Hirao | + | [[Category: Inoue M]] |
| - | [[Category: Inoue | + | [[Category: Kasashima K]] |
| - | [[Category: Kasashima | + | [[Category: Kawai G]] |
| - | [[Category: Kawai | + | [[Category: Kigawa T]] |
| - | [[Category: Kigawa | + | [[Category: Kim I-S]] |
| - | [[Category: Kim | + | [[Category: Muto Y]] |
| - | [[Category: Muto | + | [[Category: Sakamoto H]] |
| - | [[Category: Sakamoto | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
SOLUTION STRUCTURE OF THE HUC RBD1-RBD2 COMPLEXED WITH THE AU-RICH ELEMENT
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Categories: Large Structures | Mus musculus | Hirao M | Inoue M | Kasashima K | Kawai G | Kigawa T | Kim I-S | Muto Y | Sakamoto H | Yokoyama S
