This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1fq4
From Proteopedia
(Difference between revisions)
m (Protected "1fq4" [edit=sysop:move=sysop]) |
|||
| (9 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:1fq4.png|left|200px]] | ||
| - | + | ==CRYSTAL STRUCTURE OF A COMPLEX BETWEEN HYDROXYETHYLENE INHIBITOR CP-108,420 AND YEAST ASPARTIC PROTEINASE A== | |
| - | + | <StructureSection load='1fq4' size='340' side='right'caption='[[1fq4]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1fq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FQ4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2Y2:N-[(2R)-1-{[(2S,3R,5R)-1-CYCLOHEXYL-3-HYDROXY-5-{[2-(MORPHOLIN-4-YL)ETHYL]CARBAMOYL}OCT-7-YN-2-YL]AMINO}-3-(METHYLSULFANYL)-1-OXOPROPAN-2-YL]-1H-BENZIMIDAZOLE-2-CARBOXAMIDE'>2Y2</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fq4 OCA], [https://pdbe.org/1fq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fq4 RCSB], [https://www.ebi.ac.uk/pdbsum/1fq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fq4 ProSAT]</span></td></tr> |
| - | [[1fq4]] is a 1 chain structure | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CARP_YEAST CARP_YEAST] Aspartyl protease implicated in the post-translational regulation of S.cerevisiae vacuolar proteinases. Acts on YSCB, on YSCY and on itself. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fq/1fq4_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fq4 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Pepsin|Pepsin]] | *[[Pepsin|Pepsin]] | ||
| - | + | *[[Proteinase 3D structures|Proteinase 3D structures]] | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | + | [[Category: Badasso MO]] | |
| - | [[Category: Badasso | + | [[Category: Cooper JB]] |
| - | [[Category: Cooper | + | [[Category: Cronin NB]] |
| - | [[Category: Cronin | + | [[Category: Dreyer T]] |
| - | [[Category: Dreyer | + | [[Category: Hoover DJ]] |
| - | [[Category: Hoover | + | [[Category: Humblet CC]] |
| - | [[Category: Humblet | + | [[Category: Lunney EA]] |
| - | [[Category: Lunney | + | [[Category: Rosati RL]] |
| - | [[Category: Rosati | + | [[Category: Tickle IJ]] |
| - | [[Category: Tickle | + | |
| - | + | ||
| - | + | ||
Current revision
CRYSTAL STRUCTURE OF A COMPLEX BETWEEN HYDROXYETHYLENE INHIBITOR CP-108,420 AND YEAST ASPARTIC PROTEINASE A
| |||||||||||
