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1frt

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(New page: 200px<br /><applet load="1frt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1frt, resolution 4.5&Aring;" /> '''CRYSTAL STRUCTURE OF ...)
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[[Image:1frt.gif|left|200px]]<br /><applet load="1frt" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1frt, resolution 4.5&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC==
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The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG), to the bloodstream of the newborn. FcRn is structurally similar to class I, major histocompatibility complex (MHC) molecules, despite differences in, the ligands they bind (the Fc portion of IgG and antigenic peptides, respectively). A low-resolution crystal structure of the complex between, FcRn and Fc localizes the binding site for Fc to the side of FcRn, distinct from the tops of the alpha 1 and alpha 2 domains which serve as, the peptide and T-cell receptor binding sites in class I molecules. FcRn, binds to Fc at the interface between the Fc CH2 and CH3 domains, which, contains several histidine residues that could account for the sharply, pH-dependent FcRn/IgG interaction. A dimer of FcRn heterodimers observed, in the co-crystals and in the crystals of FcRn alone could be involved in, binding Fc, correlating with the 2:1 binding stoichiometry between FcRn, and IgG (ref. 4) and suggesting an unusual orientation of FcRn on the, membrane.
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<StructureSection load='1frt' size='340' side='right'caption='[[1frt]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1frt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FRT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FRT FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1frt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1frt OCA], [https://pdbe.org/1frt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1frt RCSB], [https://www.ebi.ac.uk/pdbsum/1frt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1frt ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FCGRN_RAT FCGRN_RAT] Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/1frt_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1frt ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1FRT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FRT OCA].
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of the complex of rat neonatal Fc receptor with Fc., Burmeister WP, Huber AH, Bjorkman PJ, Nature. 1994 Nov 24;372(6504):379-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7969498 7969498]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Bjorkman, P.J.]]
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[[Category: Bjorkman PJ]]
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[[Category: Burmeister, W.P.]]
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[[Category: Burmeister WP]]
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[[Category: NAG]]
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[[Category: complex (receptor/immunoglobulin)]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 15:12:31 2007''
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Current revision

CRYSTAL STRUCTURE OF THE COMPLEX OF RAT NEONATAL FC RECEPTOR WITH FC

PDB ID 1frt

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