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1frv

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[[Image:1frv.gif|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE OXIDIZED FORM OF NI-FE HYDROGENASE==
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The line below this paragraph, containing "STRUCTURE_1frv", creates the "Structure Box" on the page.
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<StructureSection load='1frv' size='340' side='right'caption='[[1frv]], [[Resolution|resolution]] 2.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1frv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Megalodesulfovibrio_gigas Megalodesulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FRV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FRV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FEL:HYDRATED+FE'>FEL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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{{STRUCTURE_1frv| PDB=1frv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1frv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1frv OCA], [https://pdbe.org/1frv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1frv RCSB], [https://www.ebi.ac.uk/pdbsum/1frv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1frv ProSAT]</span></td></tr>
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</table>
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'''CRYSTAL STRUCTURE OF THE OXIDIZED FORM OF NI-FE HYDROGENASE'''
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== Function ==
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[https://www.uniprot.org/uniprot/PHNS_MEGGA PHNS_MEGGA]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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The X-ray structure of the heterodimeric Ni-Fe hydrogenase from Desulfovibrio gigas, the enzyme responsible for the metabolism of molecular hydrogen, has been solved at 2.85 A resolution. The active site, which appears to contain, besides nickel, a second metal ion, is buried in the 60K subunit. The 28K subunit, which coordinates one [3Fe-4S] and two [4Fe-4S] clusters, contains an amino-terminal domain with similarities to the redox protein flavodoxin. The structure suggests plausible electron and proton transfer pathways.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fr/1frv_consurf.spt"</scriptWhenChecked>
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1FRV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Desulfovibrio_gigas Desulfovibrio gigas]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FRV OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Crystal structure of the nickel-iron hydrogenase from Desulfovibrio gigas., Volbeda A, Charon MH, Piras C, Hatchikian EC, Frey M, Fontecilla-Camps JC, Nature. 1995 Feb 16;373(6515):580-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7854413 7854413]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1frv ConSurf].
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[[Category: Cytochrome-c3 hydrogenase]]
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<div style="clear:both"></div>
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[[Category: Desulfovibrio gigas]]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Fontecilla-Camps, J C.]]
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[[Category: Large Structures]]
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[[Category: Frey, M.]]
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[[Category: Megalodesulfovibrio gigas]]
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[[Category: Volbeda, A.]]
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[[Category: Fontecilla-Camps JC]]
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[[Category: Ni-fe hydrogenase]]
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[[Category: Frey M]]
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[[Category: Oxidoreductase]]
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[[Category: Volbeda A]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:41:35 2008''
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Current revision

CRYSTAL STRUCTURE OF THE OXIDIZED FORM OF NI-FE HYDROGENASE

PDB ID 1frv

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