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1fss

From Proteopedia

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(New page: 200px <!-- The line below this paragraph, containing "STRUCTURE_1fss", creates the "Structure Box" on the page. You may change the PDB parameter (which sets the PD...)
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[[Image:1fss.png|left|200px]]
 
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==ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II==
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The line below this paragraph, containing "STRUCTURE_1fss", creates the "Structure Box" on the page.
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<StructureSection load='1fss' size='340' side='right'caption='[[1fss]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fss]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] and [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FSS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1fss| PDB=1fss | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fss FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fss OCA], [https://pdbe.org/1fss PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fss RCSB], [https://www.ebi.ac.uk/pdbsum/1fss PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fss ProSAT]</span></td></tr>
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</table>
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===ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II===
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== Function ==
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[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_8747462}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 8747462 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/1fss_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_8747462}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[1fss]] is a 2 chain structure of [[Acetylcholinesterase]] and [[Fasciculin]] with sequence from [http://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps] and [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FSS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fss ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[AChE inhibitors and substrates|AChE inhibitors and substrates]]
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*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
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*[[Acetylcholinesterase|Acetylcholinesterase]]
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*[[Acetylcholinesterase: Substrate Traffic and Inhibition|Acetylcholinesterase: Substrate Traffic and Inhibition]]
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*[[Fasciculin|Fasciculin]]
*[[Fasciculin|Fasciculin]]
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*[[Group:SMART:Acetylcholinesterase:A Story of Substrate Traffic and Inhibition by Green Mamba Snake Toxin|SMART:Acetylcholinesterase:A Story of Substrate Traffic and Inhibition by Green Mamba Snake Toxin]]
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__TOC__
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*[[Structure Gallery Generator|Structure Gallery Generator]]
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:008747462</ref><references group="xtra"/>
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[[Category: Acetylcholinesterase]]
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[[Category: Dendroaspis angusticeps]]
[[Category: Dendroaspis angusticeps]]
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[[Category: Torpedo californica]]
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[[Category: Large Structures]]
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[[Category: Harel, M.]]
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[[Category: Tetronarce californica]]
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[[Category: Kleywegt, G J.]]
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[[Category: Harel M]]
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[[Category: Silman, I.]]
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[[Category: Kleywegt GJ]]
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[[Category: Sussman, J L.]]
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[[Category: Silman I]]
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[[Category: Sussman JL]]

Current revision

ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH FASCICULIN-II

PDB ID 1fss

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