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1fyv

From Proteopedia

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{{Seed}}
 
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[[Image:1fyv.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1==
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The line below this paragraph, containing "STRUCTURE_1fyv", creates the "Structure Box" on the page.
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<StructureSection load='1fyv' size='340' side='right'caption='[[1fyv]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1fyv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FYV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_1fyv| PDB=1fyv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fyv OCA], [https://pdbe.org/1fyv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fyv RCSB], [https://www.ebi.ac.uk/pdbsum/1fyv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fyv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TLR1_HUMAN TLR1_HUMAN] Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fy/1fyv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fyv ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1===
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==See Also==
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11081518}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11081518 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11081518}}
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==About this Structure==
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1FYV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FYV OCA].
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==Reference==
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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains., Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L, Nature. 2000 Nov 2;408(6808):111-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11081518 11081518]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Horng, T.]]
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[[Category: Horng T]]
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[[Category: Manley, J L.]]
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[[Category: Manley JL]]
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[[Category: Medzhitov, R.]]
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[[Category: Medzhitov R]]
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[[Category: Shen, B.]]
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[[Category: Shen B]]
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[[Category: Tao, X.]]
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[[Category: Tao X]]
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[[Category: Tong, L.]]
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[[Category: Tong L]]
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[[Category: Xu, Y.]]
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[[Category: Xu Y]]
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[[Category: Beta-alpha-beta fold parallel beta sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:08:52 2008''
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Current revision

CRYSTAL STRUCTURE OF THE TIR DOMAIN OF HUMAN TLR1

PDB ID 1fyv

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