This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1fzm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "1fzm" [edit=sysop:move=sysop])
Current revision (11:18, 27 March 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1fzm.png|left|200px]]
 
-
{{STRUCTURE_1fzm| PDB=1fzm | SCENE= }}
+
==MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN==
-
 
+
<StructureSection load='1fzm' size='340' side='right'caption='[[1fzm]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
===MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN===
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[1fzm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Vesicular_stomatitis_Indiana_virus_strain_Glasgow Vesicular stomatitis Indiana virus strain Glasgow]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FZM FirstGlance]. <br>
-
{{ABSTRACT_PUBMED_11290333}}
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
==About this Structure==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fzm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fzm OCA], [https://pdbe.org/1fzm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fzm RCSB], [https://www.ebi.ac.uk/pdbsum/1fzm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fzm ProSAT]</span></td></tr>
-
[[1fzm]] is a 3 chain structure of [[Beta-2 microglobulin]] and [[Major histocompatibility complex]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FZM OCA].
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/NCAP_VSIVG NCAP_VSIVG] Encapsidates the genome in a ratio of one N per nine ribonucleotides, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Replication is dependent on intracellular concentration of newly synthesized N, termed N(0), which corresponds to the protein not associated with RNA. In contrast, when associated with RNA, it is termed N. During replication, encapsidation by N(0) is coupled to RNA synthesis and all replicative products are resistant to nucleases (By similarity).
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fz/1fzm_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1fzm ConSurf].
 +
<div style="clear:both"></div>
==See Also==
==See Also==
-
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
+
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-
*[[Major histocompatibility complex|Major histocompatibility complex]]
+
*[[MHC 3D structures|MHC 3D structures]]
-
 
+
*[[MHC I 3D structures|MHC I 3D structures]]
-
==Reference==
+
__TOC__
-
<ref group="xtra">PMID:011290333</ref><references group="xtra"/>
+
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Brunmark, A.]]
+
[[Category: Vesicular stomatitis Indiana virus strain Glasgow]]
-
[[Category: Jackson, M R.]]
+
[[Category: Brunmark A]]
-
[[Category: Mattsson, N.]]
+
[[Category: Jackson MR]]
-
[[Category: Peterson, P A.]]
+
[[Category: Mattsson N]]
-
[[Category: Rudolph, M G.]]
+
[[Category: Peterson PA]]
-
[[Category: Speir, J A.]]
+
[[Category: Rudolph MG]]
-
[[Category: Teyton, L.]]
+
[[Category: Speir JA]]
-
[[Category: Wilson, I A.]]
+
[[Category: Teyton L]]
-
[[Category: Immune system]]
+
[[Category: Wilson IA]]
-
[[Category: Major histocompatibility complex peptide-mhc]]
+

Current revision

MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN

PDB ID 1fzm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fzm"
Personal tools