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1g4f

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{{Seed}}
 
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[[Image:1g4f.png|left|200px]]
 
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<!--
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==NMR STRUCTURE OF THE FIFTH DOMAIN OF HUMAN BETA2-GLYCOPROTEIN I==
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The line below this paragraph, containing "STRUCTURE_1g4f", creates the "Structure Box" on the page.
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<StructureSection load='1g4f' size='340' side='right'caption='[[1g4f]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g4f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G4F FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g4f OCA], [https://pdbe.org/1g4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g4f RCSB], [https://www.ebi.ac.uk/pdbsum/1g4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g4f ProSAT]</span></td></tr>
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{{STRUCTURE_1g4f| PDB=1g4f | SCENE= }}
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</table>
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== Function ==
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===NMR STRUCTURE OF THE FIFTH DOMAIN OF HUMAN BETA2-GLYCOPROTEIN I===
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[https://www.uniprot.org/uniprot/APOH_HUMAN APOH_HUMAN] Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_11124037}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 11124037 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/1g4f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_11124037}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g4f ConSurf].
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1G4F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G4F OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Identification of the phospholipid-binding site of human beta(2)-glycoprotein I domain V by heteronuclear magnetic resonance., Hoshino M, Hagihara Y, Nishii I, Yamazaki T, Kato H, Goto Y, J Mol Biol. 2000 Dec 15;304(5):927-39. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11124037 11124037]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Goto, Y.]]
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[[Category: Goto Y]]
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[[Category: Hagihara, Y.]]
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[[Category: Hagihara Y]]
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[[Category: Hoshino, M.]]
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[[Category: Hoshino M]]
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[[Category: Kato, H.]]
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[[Category: Kato H]]
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[[Category: Nishii, I.]]
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[[Category: Nishii I]]
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[[Category: Yamazaki, T.]]
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[[Category: Yamazaki T]]
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[[Category: Short consensus repeat]]
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[[Category: Sushi-domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 04:23:55 2008''
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Current revision

NMR STRUCTURE OF THE FIFTH DOMAIN OF HUMAN BETA2-GLYCOPROTEIN I

PDB ID 1g4f

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