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1g8q

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{{Seed}}
 
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[[Image:1g8q.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF HUMAN CD81 EXTRACELLULAR DOMAIN, A RECEPTOR FOR HEPATITIS C VIRUS==
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The line below this paragraph, containing "STRUCTURE_1g8q", creates the "Structure Box" on the page.
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<StructureSection load='1g8q' size='340' side='right'caption='[[1g8q]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1g8q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G8Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1G8Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1g8q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g8q OCA], [https://pdbe.org/1g8q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1g8q RCSB], [https://www.ebi.ac.uk/pdbsum/1g8q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1g8q ProSAT]</span></td></tr>
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{{STRUCTURE_1g8q| PDB=1g8q | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN] Defects in CD81 are the cause of immunodeficiency common variable type 6 (CVID6) [MIM:[https://omim.org/entry/613496 613496]; also called antibody deficiency due to CD81 defect. CVID6 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20237408</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CD81_HUMAN CD81_HUMAN] May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/1g8q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1g8q ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF HUMAN CD81 EXTRACELLULAR DOMAIN, A RECEPTOR FOR HEPATITIS C VIRUS===
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==See Also==
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*[[CD81|CD81]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11226150 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11226150}}
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==About this Structure==
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1G8Q is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G8Q OCA].
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==Reference==
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<ref group="xtra">PMID:11226150</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bolognesi, M.]]
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[[Category: Large Structures]]
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[[Category: Bordo, D.]]
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[[Category: Bolognesi M]]
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[[Category: Falugi, F.]]
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[[Category: Bordo D]]
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[[Category: Galli, G.]]
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[[Category: Falugi F]]
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[[Category: Grandi, G.]]
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[[Category: Galli G]]
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[[Category: Kitadokoro, K.]]
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[[Category: Grandi G]]
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[[Category: Petracca, R.]]
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[[Category: Kitadokoro K]]
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[[Category: Alpha helical]]
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[[Category: Petracca R]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:42:20 2009''
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Current revision

CRYSTAL STRUCTURE OF HUMAN CD81 EXTRACELLULAR DOMAIN, A RECEPTOR FOR HEPATITIS C VIRUS

PDB ID 1g8q

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