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1gk0

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[[Image:1gk0.png|left|200px]]
 
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{{STRUCTURE_1gk0| PDB=1gk0 | SCENE= }}
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==Structure-based prediction of modifications in glutarylamidase to allow single-step enzymatic production of 7-aminocephalosporanic acid from cephalosporin C==
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<StructureSection load='1gk0' size='340' side='right'caption='[[1gk0]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gk0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_sp. Pseudomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GK0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GK0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gk0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gk0 OCA], [https://pdbe.org/1gk0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gk0 RCSB], [https://www.ebi.ac.uk/pdbsum/1gk0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gk0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/G7AC_PSEU7 G7AC_PSEU7] Catalyzes the deacylation of 7 beta-(4-carboxybutanamido)cephalosporanic acid (glutaryl-7-aminocephalosporanic acid or GL-7-ACA) to 7-aminocephalosporanic acid (7-ACA).<ref>PMID:2993240</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/1gk0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gk0 ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE-BASED PREDICTION OF MODIFICATIONS IN GLUTARYLAMIDASE TO ALLOW SINGLE-STEP ENZYMATIC PRODUCTION OF 7-AMINOCEPHALOSPORANIC ACID FROM CEPHALOSPORIN C===
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==See Also==
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*[[Cephalosporin acylase 3D structures|Cephalosporin acylase 3D structures]]
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{{ABSTRACT_PUBMED_11742126}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[1gk0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_sp. Pseudomonas sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GK0 OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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[[Category: Pseudomonas sp]]
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<ref group="xtra">PMID:011742126</ref><references group="xtra"/>
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[[Category: Aretz W]]
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[[Category: Penicillin amidase]]
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[[Category: Fritz-Wolf K]]
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[[Category: Pseudomonas sp.]]
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[[Category: Kabsch W]]
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[[Category: Aretz, W.]]
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[[Category: Koller KP]]
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[[Category: Fritz-Wolf, K.]]
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[[Category: Lange G]]
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[[Category: Kabsch, W.]]
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[[Category: Liesum A]]
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[[Category: Koller, K P.]]
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[[Category: Sauber K]]
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[[Category: Lange, G.]]
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[[Category: Schreuder H]]
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[[Category: Liesum, A.]]
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[[Category: Sauber, K.]]
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[[Category: Schreuder, H.]]
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[[Category: Catalytic triad]]
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[[Category: Cephalosporin acylase]]
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[[Category: Cephalosporin c]]
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[[Category: Glutaryl acylase]]
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[[Category: Hydrolase]]
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[[Category: Ntn-hydrolase]]
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[[Category: X-raz structure]]
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Current revision

Structure-based prediction of modifications in glutarylamidase to allow single-step enzymatic production of 7-aminocephalosporanic acid from cephalosporin C

PDB ID 1gk0

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