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1gkn

From Proteopedia

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[[Image:1gkn.gif|left|200px]]
 
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{{Structure
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==Structure Determination and Rational Mutagenesis reveal binding surface of immune adherence receptor, CR1 (CD35)==
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|PDB= 1gkn |SIZE=350|CAPTION= <scene name='initialview01'>1gkn</scene>
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<StructureSection load='1gkn' size='340' side='right'caption='[[1gkn]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1gkn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GKN FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gkn OCA], [https://pdbe.org/1gkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gkn RCSB], [https://www.ebi.ac.uk/pdbsum/1gkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gkn ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''STRUCTURE DETERMINATION AND RATIONAL MUTAGENESIS REVEAL BINDING SURFACE OF IMMUNE ADHERENCE RECEPTOR, CR1 (CD35)'''
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[https://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN] Mediates cellular binding of particles and immune complexes that have activated complement.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Complement receptor type 1 (CR1 or CD35) is a multiple modular protein that mediates the immune adherence phenomenon, a fundamental event for destroying microbes and initiating an immunological response. It fulfills this role through binding C3b/C4b-opsonized foreign antigens. The structure of the principal C3b/C4b binding site (residues 901-1095) of CR1 is reported, revealing three complement control protein modules (modules 15-17) in an extended head-to-tail arrangement with flexibility at the 16-17 junction. Structure-guided mutagenesis identified a positively charged surface region on module 15 that is critical for C4b binding. This patch, together with basic side chains of module 16 exposed on the same face of CR1, is required for C3b binding. These studies reveal the initial structural details of one of the first receptor-ligand interactions to be identified in immunobiology.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/1gkn_consurf.spt"</scriptWhenChecked>
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==Disease==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Known diseases associated with this structure: Blood group, Knops system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], CR1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], Malaria, severe, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], SLE susceptibility OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]]
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gkn ConSurf].
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1GKN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKN OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor., Smith BO, Mallin RL, Krych-Goldberg M, Wang X, Hauhart RE, Bromek K, Uhrin D, Atkinson JP, Barlow PN, Cell. 2002 Mar 22;108(6):769-80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11955431 11955431]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Atkinson, J P.]]
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[[Category: Atkinson JP]]
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[[Category: Barlow, P N.]]
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[[Category: Barlow PN]]
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[[Category: Bromek, K.]]
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[[Category: Bromek K]]
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[[Category: Hauhart, R E.]]
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[[Category: Hauhart RE]]
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[[Category: Krych-Goldberg, M.]]
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[[Category: Krych-Goldberg M]]
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[[Category: Mallin, R L.]]
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[[Category: Mallin RL]]
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[[Category: Smith, B O.]]
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[[Category: Smith BO]]
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[[Category: Uhrin, D.]]
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[[Category: Uhrin D]]
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[[Category: Wang, X.]]
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[[Category: Wang X]]
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[[Category: complement]]
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[[Category: module]]
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[[Category: scr]]
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[[Category: structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:24:24 2008''
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Current revision

Structure Determination and Rational Mutagenesis reveal binding surface of immune adherence receptor, CR1 (CD35)

PDB ID 1gkn

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