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1gm7

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{{Seed}}
 
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[[Image:1gm7.png|left|200px]]
 
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==Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism==
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The line below this paragraph, containing "STRUCTURE_1gm7", creates the "Structure Box" on the page.
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<StructureSection load='1gm7' size='340' side='right'caption='[[1gm7]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gm7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GM7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GM7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PNN:PENICILLIN+G'>PNN</scene>, <scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene></td></tr>
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{{STRUCTURE_1gm7| PDB=1gm7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gm7 OCA], [https://pdbe.org/1gm7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gm7 RCSB], [https://www.ebi.ac.uk/pdbsum/1gm7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gm7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAC_ECOLX PAC_ECOLX]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gm/1gm7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gm7 ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURES OF PENICILLIN ACYLASE ENZYME-SUBSTRATE COMPLEXES: STRUCTURAL INSIGHTS INTO THE CATALYTIC MECHANISM===
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==See Also==
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*[[Penicillin acylase|Penicillin acylase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11601852}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11601852 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11601852}}
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==About this Structure==
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1GM7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GM7 OCA].
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==Reference==
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Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism., McVey CE, Walsh MA, Dodson GG, Wilson KS, Brannigan JA, J Mol Biol. 2001 Oct 12;313(1):139-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11601852 11601852]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Penicillin amidase]]
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: Brannigan JA]]
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[[Category: Brannigan, J A.]]
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[[Category: Dodson GG]]
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[[Category: Dodson, G G.]]
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[[Category: McVey CE]]
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[[Category: Mcvey, C E.]]
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[[Category: Walsh MA]]
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[[Category: Walsh, M A.]]
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[[Category: Wilson KS]]
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[[Category: Wilson, K S.]]
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[[Category: Antibiotic resistance]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:30:23 2008''
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Current revision

Crystal structures of penicillin acylase enzyme-substrate complexes: Structural insights into the catalytic mechanism

PDB ID 1gm7

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