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1gnc

From Proteopedia

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{{Seed}}
 
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[[Image:1gnc.png|left|200px]]
 
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==STRUCTURE AND DYNAMICS OF THE HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR DETERMINED BY NMR SPECTROSCOPY. LOOP MOBILITY IN A FOUR-HELIX-BUNDLE PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1gnc", creates the "Structure Box" on the page.
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<StructureSection load='1gnc' size='340' side='right'caption='[[1gnc]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gnc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GNC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gnc OCA], [https://pdbe.org/1gnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gnc RCSB], [https://www.ebi.ac.uk/pdbsum/1gnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gnc ProSAT]</span></td></tr>
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{{STRUCTURE_1gnc| PDB=1gnc | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSF3_HUMAN CSF3_HUMAN] Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gn/1gnc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gnc ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE AND DYNAMICS OF THE HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR DETERMINED BY NMR SPECTROSCOPY. LOOP MOBILITY IN A FOUR-HELIX-BUNDLE PROTEIN===
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==See Also==
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*[[Colony-stimulating factor 3D structures|Colony-stimulating factor 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_7518249}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7518249 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7518249}}
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==About this Structure==
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1GNC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GNC OCA].
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==Reference==
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Structure and dynamics of the human granulocyte colony-stimulating factor determined by NMR spectroscopy. Loop mobility in a four-helix-bundle protein., Zink T, Ross A, Luers K, Cieslar C, Rudolph R, Holak TA, Biochemistry. 1994 Jul 19;33(28):8453-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7518249 7518249]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Holak, T A.]]
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[[Category: Holak TA]]
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[[Category: Ross, A.]]
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[[Category: Ross A]]
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[[Category: Rudolph, R.]]
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[[Category: Rudolph R]]
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[[Category: Zink, T W.]]
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[[Category: Zink TW]]
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[[Category: Growth factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 05:33:15 2008''
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Current revision

STRUCTURE AND DYNAMICS OF THE HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR DETERMINED BY NMR SPECTROSCOPY. LOOP MOBILITY IN A FOUR-HELIX-BUNDLE PROTEIN

PDB ID 1gnc

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