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1gq2

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Malic Enzyme from Pigeon Liver

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OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gq2"

Categories: Columba livia | Large Structures | Liang T | Yang Z | Zhang H

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-[[Image:1gq2.gif|left|200px]]<br />
-<applet load="1gq2" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1gq2, resolution 2.5&Aring;" />
-'''MALIC ENZYME FROM PIGEON LIVER'''<br />
-==Overview==
+==Malic Enzyme from Pigeon Liver==
-Malic enzymes are widely distributed in nature, and have important, biological functions. They catalyze the oxidative decarboxylation of, malate to produce pyruvate and CO(2) in the presence of divalent cations, (Mg(2+), Mn(2+)). Most malic enzymes have a clear selectivity for the, dinucleotide cofactor, being able to use either NAD(+) or NADP(+), but not, both. Structural studies of the human mitochondrial NAD(+)-dependent malic, enzyme established that malic enzymes belong to a new class of oxidative, decarboxylases. Here we report the crystal structure of the pigeon, cytosolic NADP(+)-dependent malic enzyme, in a closed form, in a, quaternary complex with NADP(+), Mn(2+), and oxalate. This represents the, first structural information on an NADP(+)-dependent malic enzyme. Despite, the ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11790843 (full description)]]
+<StructureSection load='1gq2' size='340' side='right'caption='[[1gq2]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1gq2]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Columba_livia Columba livia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GQ2 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gq2 OCA], [https://pdbe.org/1gq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gq2 RCSB], [https://www.ebi.ac.uk/pdbsum/1gq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gq2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/MAOX_COLLI MAOX_COLLI]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gq/1gq2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gq2 ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-GQ2 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Columba_livia Columba livia]] with OXL, MN, CL, NA and NAP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.40 1.1.1.40]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GQ2 OCA]].
+*[[NADP-dependent malic enzyme|NADP-dependent malic enzyme]]
+__TOC__
-==Reference==
+</StructureSection>
-Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme., Yang Z, Zhang H, Hung HC, Kuo CC, Tsai LC, Yuan HS, Chou WY, Chang GG, Tong L, Protein Sci. 2002 Feb;11(2):332-41. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11790843 11790843]
 [[Category: Columba livia]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Liang, T.]]
+[[Category: Liang T]]
-[[Category: Yang, Z.]]
+[[Category: Yang Z]]
-[[Category: Zhang, H.]]
+[[Category: Zhang H]]
-[[Category: CL]]
-[[Category: MN]]
-[[Category: NA]]
-[[Category: NAP]]
-[[Category: OXL]]
-[[Category: crystal structure]]
-[[Category: decarboxylase]]
-[[Category: malate]]
-[[Category: malic enzyme]]
-[[Category: mn2+]]
-[[Category: nad-nadp selectivity]]
-[[Category: nadp-dependent]]
-[[Category: pigeon liver]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 22:07:00 2007''

1gq2

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Malic Enzyme from Pigeon Liver

Structural highlights

Function

Evolutionary Conservation

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