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1guw

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{{Seed}}
 
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[[Image:1guw.png|left|200px]]
 
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==STRUCTURE OF THE CHROMODOMAIN FROM MOUSE HP1beta IN COMPLEX WITH THE LYSINE 9-METHYL HISTONE H3 N-TERMINAL PEPTIDE, NMR, 25 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1guw", creates the "Structure Box" on the page.
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<StructureSection load='1guw' size='340' side='right'caption='[[1guw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1guw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GUW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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{{STRUCTURE_1guw| PDB=1guw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1guw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1guw OCA], [https://pdbe.org/1guw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1guw RCSB], [https://www.ebi.ac.uk/pdbsum/1guw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1guw ProSAT]</span></td></tr>
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</table>
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===STRUCTURE OF THE CHROMODOMAIN FROM MOUSE HP1BETA IN COMPLEX WITH THE LYSINE 9-METHYL HISTONE H3 N-TERMINAL PEPTIDE, NMR, 25 STRUCTURES===
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== Function ==
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[https://www.uniprot.org/uniprot/CBX1_MOUSE CBX1_MOUSE] Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11882902}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11882902 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gu/1guw_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11882902}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1GUW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GUW OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1guw ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9., Nielsen PR, Nietlispach D, Mott HR, Callaghan J, Bannister A, Kouzarides T, Murzin AG, Murzina NV, Laue ED, Nature. 2002 Mar 7;416(6876):103-7. Epub 2002 Feb 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11882902 11882902]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Bannister A]]
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[[Category: Bannister, A.]]
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[[Category: Callaghan JM]]
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[[Category: Callaghan, J M.]]
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[[Category: Kouzarides T]]
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[[Category: Kouzarides, T.]]
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[[Category: Laue ED]]
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[[Category: Laue, E D.]]
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[[Category: Mott HR]]
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[[Category: Mott, H R.]]
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[[Category: Murzin AG]]
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[[Category: Murzin, A G.]]
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[[Category: Murzina NV]]
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[[Category: Murzina, N V.]]
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[[Category: Nielsen PR]]
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[[Category: Nielsen, P R.]]
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[[Category: Nietlispach D]]
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[[Category: Nietlispach, D.]]
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[[Category: Chromatin-binding]]
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[[Category: Heterochromatin]]
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[[Category: Histone modification]]
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[[Category: Lysine methylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:07:19 2008''
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Current revision

STRUCTURE OF THE CHROMODOMAIN FROM MOUSE HP1beta IN COMPLEX WITH THE LYSINE 9-METHYL HISTONE H3 N-TERMINAL PEPTIDE, NMR, 25 STRUCTURES

PDB ID 1guw

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