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1gv8

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{{Seed}}
 
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[[Image:1gv8.png|left|200px]]
 
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==18 kDa fragment of N-II domain of duck ovotransferrin==
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The line below this paragraph, containing "STRUCTURE_1gv8", creates the "Structure Box" on the page.
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<StructureSection load='1gv8' size='340' side='right'caption='[[1gv8]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gv8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GV8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
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{{STRUCTURE_1gv8| PDB=1gv8 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gv8 OCA], [https://pdbe.org/1gv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gv8 RCSB], [https://www.ebi.ac.uk/pdbsum/1gv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gv8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFE_ANAPL TRFE_ANAPL] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. Ovotransferrin has a bacteriostatic function. Its concentration in avian egg is the highest concentration of any transferrin in vivo (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gv/1gv8_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gv8 ConSurf].
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<div style="clear:both"></div>
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===18 KDA FRAGMENT OF N-II DOMAIN OF DUCK OVOTRANSFERRIN===
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==See Also==
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*[[Transferrin 3D structures|Transferrin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_11976488}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11976488 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11976488}}
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==About this Structure==
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1GV8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anas_platyrhynchos Anas platyrhynchos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GV8 OCA].
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==Reference==
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The mechanism of iron uptake by transferrins: the X-ray structures of the 18 kDa NII domain fragment of duck ovotransferrin and its nitrilotriacetate complex., Kuser P, Hall DR, Haw ML, Neu M, Evans RW, Lindley PF, Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):777-83. Epub 2002, Apr 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11976488 11976488]
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[[Category: Anas platyrhynchos]]
[[Category: Anas platyrhynchos]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hall, D R.]]
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[[Category: Hall DR]]
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[[Category: Haw, M L.]]
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[[Category: Haw ML]]
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[[Category: Kuser, P.]]
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[[Category: Kuser P]]
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[[Category: Lindley, P F.]]
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[[Category: Lindley PF]]
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[[Category: Neu, M.]]
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[[Category: Neu M]]
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[[Category: Glycoprotein]]
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[[Category: Iron transport]]
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[[Category: Metal-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 06:08:23 2008''
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Current revision

18 kDa fragment of N-II domain of duck ovotransferrin

PDB ID 1gv8

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