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1gzb

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[[Image:1gzb.gif|left|200px]]
 
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==PEROXIDASE==
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The line below this paragraph, containing "STRUCTURE_1gzb", creates the "Structure Box" on the page.
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<StructureSection load='1gzb' size='340' side='right'caption='[[1gzb]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1gzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Agaricales_sp._'Arthromyces_ramosus' Agaricales sp. 'Arthromyces ramosus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GZB FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1gzb| PDB=1gzb | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gzb OCA], [https://pdbe.org/1gzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gzb RCSB], [https://www.ebi.ac.uk/pdbsum/1gzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gzb ProSAT]</span></td></tr>
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</table>
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'''PEROXIDASE'''
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== Function ==
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[https://www.uniprot.org/uniprot/PER_ARTRA PER_ARTRA]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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In the presence of ammonium sulfate the absorption spectra of a peroxidase from the fungus Arthromyces ramosus (ARP) showed that the low-spin component increased as the pH increased from 6.0 to 9.0, whereas in its absence ARP remained in the high-spin state in the pH range investigated. The crystal structure of ARP at pH 4.5 in the presence of ammonium sulfate at 1.8 A resolution showed that the electron density at the 6th position of the heme iron seen at pH 7.5 had disappeared and that the iron atom deviated markedly from the heme plane. These observations strongly suggest that under physiological conditions the heme of ARP is in the pentacoordinated high-spin state and that at a high pH the heme iron is able to bind ammonia, forming the low-spin state. The location of the water molecule at the distal side of the heme in peroxidases is also discussed.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gz/1gzb_consurf.spt"</scriptWhenChecked>
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1GZB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GZB OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Pentacoordination of the heme iron of Arthromyces ramosus peroxidase shown by a 1.8 A resolution crystallographic study at pH 4.5., Kunishima N, Amada F, Fukuyama K, Kawamoto M, Matsunaga T, Matsubara H, FEBS Lett. 1996 Jan 15;378(3):291-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8557120 8557120]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gzb ConSurf].
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[[Category: Eukaryota]]
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<div style="clear:both"></div>
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[[Category: Peroxidase]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Amada, F.]]
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[[Category: Agaricales sp. 'Arthromyces ramosus']]
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[[Category: Fukuyama, K.]]
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[[Category: Large Structures]]
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[[Category: Kunishima, N.]]
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[[Category: Amada F]]
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[[Category: Glycoprotein]]
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[[Category: Fukuyama K]]
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[[Category: Heme]]
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[[Category: Kunishima N]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 18:12:39 2008''
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Current revision

PEROXIDASE

PDB ID 1gzb

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