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1h1p

From Proteopedia

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{{Seed}}
 
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[[Image:1h1p.png|left|200px]]
 
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<!--
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==Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058==
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The line below this paragraph, containing "STRUCTURE_1h1p", creates the "Structure Box" on the page.
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<StructureSection load='1h1p' size='340' side='right'caption='[[1h1p]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h1p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H1P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMG:6-O-CYCLOHEXYLMETHYL+GUANINE'>CMG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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{{STRUCTURE_1h1p| PDB=1h1p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h1p OCA], [https://pdbe.org/1h1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h1p RCSB], [https://www.ebi.ac.uk/pdbsum/1h1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h1p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/1h1p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h1p ConSurf].
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<div style="clear:both"></div>
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===STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH THE INHIBITOR NU2058===
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==See Also==
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*[[Cyclin 3D structures|Cyclin 3D structures]]
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*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 12244298 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12244298}}
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==About this Structure==
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1H1P is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H1P OCA].
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==Reference==
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<ref group="xtra">PMID:12244298</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Davies, T G.]]
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[[Category: Large Structures]]
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[[Category: Endicott, J A.]]
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[[Category: Davies TG]]
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[[Category: Johnson, L N.]]
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[[Category: Endicott JA]]
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[[Category: Noble, M E.M.]]
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[[Category: Johnson LN]]
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[[Category: Atp-binding]]
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[[Category: Noble MEM]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Kinase]]
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[[Category: Mitosis]]
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[[Category: Phosphorylation]]
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[[Category: Serine/threonine-protein kinase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:08:35 2009''
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Current revision

Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058

PDB ID 1h1p

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