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1h2h

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{{Seed}}
 
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[[Image:1h2h.png|left|200px]]
 
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<!--
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==Crystal structure of TM1643==
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The line below this paragraph, containing "STRUCTURE_1h2h", creates the "Structure Box" on the page.
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<StructureSection load='1h2h' size='340' side='right'caption='[[1h2h]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1h2h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H2H FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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{{STRUCTURE_1h2h| PDB=1h2h | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h2h OCA], [https://pdbe.org/1h2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h2h RCSB], [https://www.ebi.ac.uk/pdbsum/1h2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h2h ProSAT], [https://www.topsan.org/Proteins/NESGC/1h2h TOPSAN]</span></td></tr>
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</table>
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===CRYSTAL STRUCTURE OF TM1643===
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== Function ==
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[https://www.uniprot.org/uniprot/ASPD_THEMA ASPD_THEMA] Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate. Does not show aspartate oxidase activity. Is also able to catalyze the reverse reaction, i.e. the reductive amination of oxaloacetate.<ref>PMID:12496312</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_12496312}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 12496312 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h2/1h2h_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_12496312}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1H2H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H2H OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h2h ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643., Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L, J Biol Chem. 2003 Mar 7;278(10):8804-8. Epub 2002 Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12496312 12496312]
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<references/>
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[[Category: Single protein]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Savchenko A]]
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[[Category: Savchenko, A.]]
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[[Category: Tong L]]
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[[Category: Tong, L.]]
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[[Category: Yang Z]]
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[[Category: Yang, Z.]]
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[[Category: Nesg]]
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[[Category: Northeast structural genomics consortium]]
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[[Category: Possible nad-dependent oxidoreductase]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 29 03:39:12 2008''
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Current revision

Crystal structure of TM1643

PDB ID 1h2h

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