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1h59

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(New page: 200px<br /> <applet load="1h59" size="450" color="white" frame="true" align="right" spinBox="true" caption="1h59, resolution 2.1&Aring;" /> '''COMPLEX OF IGFBP-5 W...)
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[[Image:1h59.gif|left|200px]]<br />
 
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<applet load="1h59" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1h59, resolution 2.1&Aring;" />
 
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'''COMPLEX OF IGFBP-5 WITH IGF-I'''<br />
 
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==Overview==
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==Complex of IGFBP-5 with IGF-I==
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Insulin-like growth factors (IGFs) are key regulators of cell, proliferation, differentiation and transformation, and are thus pivotal in, cancer, especially breast, prostate and colon neoplasms. They are also, important in many neurological and bone disorders. Their potent mitogenic, and anti-apoptotic actions depend primarily on their availability to bind, to the cell surface IGF-I receptor. In circulation and interstitial, fluids, IGFs are largely unavailable as they are tightly associated with, IGF-binding proteins (IGFBPs) and are released after IGFBP proteolysis., Here we report the 2.1 A crystal structure of the complex of IGF-I bound, to the N-terminal IGF-binding domain of IGFBP-5 (mini-IGFBP-5), a, prototype interaction for all N-terminal domains of the IGFBP family. The, principal interactions in the complex comprise interlaced hydrophobic side, chains that protrude from both IGF-I and the IGFBP-5 fragment and a, surrounding network of polar interactions. A solvent-exposed hydrophobic, patch is located on the IGF-I pole opposite to the mini-IGFBP-5 binding, region and marks the IGF-I receptor binding site.
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<StructureSection load='1h59' size='340' side='right'caption='[[1h59]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1h59]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H59 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h59 OCA], [https://pdbe.org/1h59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h59 RCSB], [https://www.ebi.ac.uk/pdbsum/1h59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h59 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:[https://omim.org/entry/608747 608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
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== Function ==
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[https://www.uniprot.org/uniprot/IGF1_HUMAN IGF1_HUMAN] The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake.<ref>PMID:21076856</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h5/1h59_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h59 ConSurf].
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<div style="clear:both"></div>
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==Disease==
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==See Also==
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Known disease associated with this structure: Growth retardation with deafness and mental retardation due to IGF1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147440 147440]]
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*[[Insulin-like growth factor|Insulin-like growth factor]]
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*[[Insulin-like growth factor binding protein 3D structures|Insulin-like growth factor binding protein 3D structures]]
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==About this Structure==
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== References ==
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1H59 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H59 OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5., Zeslawski W, Beisel HG, Kamionka M, Kalus W, Engh RA, Huber R, Lang K, Holak TA, EMBO J. 2001 Jul 16;20(14):3638-44. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11447105 11447105]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Beisel, H.G.]]
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[[Category: Beisel HG]]
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[[Category: Engh, R.A.]]
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[[Category: Engh RA]]
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[[Category: Holak, T.A.]]
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[[Category: Holak TA]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Kalus, W.]]
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[[Category: Kalus W]]
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[[Category: Kamionka, M.]]
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[[Category: Kamionka M]]
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[[Category: Zeslawski, W.]]
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[[Category: Zeslawski W]]
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[[Category: igf binding protein]]
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[[Category: insulin]]
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[[Category: insulin-like growth factor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:13:02 2007''
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Current revision

Complex of IGFBP-5 with IGF-I

PDB ID 1h59

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