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1h76

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[[Image:1h76.gif|left|200px]]<br />
 
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<applet load="1h76" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1h76, resolution 2.15&Aring;" />
 
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'''THE CRYSTAL STRUCTURE OF DIFERRIC PORCINE SERUM TRANSFERRIN'''<br />
 
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==Overview==
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==The crystal structure of diferric porcine serum transferrin==
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The serum transferrins are monomeric proteins with a molecular mass of, around 80 kDa and are responsible for the transport of iron in, vertebrates. The three-dimensional structures of diferric porcine and, rabbit serum transferrin have been refined against X-ray diffraction data, extending to 2.15 and 2.60 A, respectively. Data for both proteins were, collected using synchrotron radiation at temperatures of 277 K. The, porcine protein crystallizes in the space group C2, with unit-cell, parameters a = 223.8, b = 44.9, c = 78.9 A, beta = 105.4 degrees with one, molecule in the asymmetric unit. The structure was solved by, molecular-replacement methods using rabbit serum transferrin as the search, model. The structure was refined using REFMAC, with a final residual of, 13.8% (R(free) = ... [[http://ispc.weizmann.ac.il/pmbin/getpm?11752780 (full description)]]
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<StructureSection load='1h76' size='340' side='right'caption='[[1h76]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1h76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The November 2002 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Ferritin and Transferrin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2002_11 10.2210/rcsb_pdb/mom_2002_11]. The January 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serum Albumin'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_1 10.2210/rcsb_pdb/mom_2003_1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H76 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h76 OCA], [https://pdbe.org/1h76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h76 RCSB], [https://www.ebi.ac.uk/pdbsum/1h76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h76 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFE_PIG TRFE_PIG] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h7/1h76_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1h76 ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1H76 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]] with NAG, CO3 and FE as [[http://en.wikipedia.org/wiki/ligands ligands]]. The following pages contain interesting information on the relation of 1H76 with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb37_1.html Serum Albumin]]. Structure known Active Site: NFE. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1H76 OCA]].
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*[[Transferrin 3D structures|Transferrin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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The crystal and molecular structures of diferric porcine and rabbit serum transferrins at resolutions of 2.15 and 2.60 A, respectively., Hall DR, Hadden JM, Leonard GA, Bailey S, Neu M, Winn M, Lindley PF, Acta Crystallogr D Biol Crystallogr. 2002 Jan;58(Pt 1):70-80. Epub 2001, Dec 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11752780 11752780]
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[[Category: Ferritin and Transferrin]]
[[Category: Ferritin and Transferrin]]
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[[Category: Large Structures]]
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[[Category: RCSB PDB Molecule of the Month]]
[[Category: Serum Albumin]]
[[Category: Serum Albumin]]
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[[Category: Single protein]]
 
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Bailey, S.]]
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[[Category: Bailey S]]
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[[Category: Hadden, J.]]
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[[Category: Hadden JM]]
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[[Category: Hall, D.R.]]
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[[Category: Hall DR]]
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[[Category: Leonard, G.A.]]
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[[Category: Leonard GA]]
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[[Category: Lindley, P.F.]]
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[[Category: Lindley PF]]
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[[Category: Neu, M.]]
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[[Category: Neu M]]
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[[Category: Winn, M.]]
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[[Category: Winn M]]
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[[Category: CO3]]
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[[Category: FE]]
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[[Category: NAG]]
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[[Category: glycoprotein]]
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[[Category: iron transport]]
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[[Category: metal-binding]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:29:22 2007''
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Current revision

The crystal structure of diferric porcine serum transferrin

PDB ID 1h76

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