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1ha6

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[[Image:1ha6.jpg|left|200px]]
 
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{{Structure
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==NMR Solution Structure of Murine CCL20/MIP-3a Chemokine==
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|PDB= 1ha6 |SIZE=350|CAPTION= <scene name='initialview01'>1ha6</scene>
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<StructureSection load='1ha6' size='340' side='right'caption='[[1ha6]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ha6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HA6 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ha6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ha6 OCA], [https://pdbe.org/1ha6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ha6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ha6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ha6 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''NMR SOLUTION STRUCTURE OF MURINE CCL20/MIP-3A CHEMOKINE'''
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[https://www.uniprot.org/uniprot/CCL20_MOUSE CCL20_MOUSE] Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (By similarity). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial attracting lymphocytes and dendritic cells towards epithelial cells (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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CCL20/MIP-3alpha is a beta-chemokine expressed in the thymus, skin, and intestinal epithelial cells that exclusively binds and activates the CCR6 receptor in both mice and humans. The strict receptor binding specificity of CCL20 is exceptional; other chemokines and their receptors bind promiscuously with multiple partners. Toward determining the structural basis for the selective receptor specificity of CCL20, we have determined its three-dimensional structure by 1H NMR spectroscopy. CCL20 exhibits the same monomeric structure previously described for other chemokines: a three-stranded beta-sheet and an overlying alpha-helix. The CCL20 receptor selectivity could arise from the rigid conformation of the N-terminal DCCL motif as well as the groove between the N-loop and the beta2-beta3 hairpin, which is significantly narrower in CCL20 than in other chemokines. Similar structural features are seen in human beta-defensin 2, a small nonchemokine polypeptide reported to selectively bind and activate CCR6, which stresses their importance for the specific binding of both CCL20 and beta-defensin 2 to CCR6. CCL20's structure will be useful to design tools aimed to modulate its important biological functions.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/1ha6_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1HA6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HA6 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ha6 ConSurf].
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NMR solution structure of murine CCL20/MIP-3alpha, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the beta-chemokine receptor CCR6., Perez-Canadillas JM, Zaballos A, Gutierrez J, Varona R, Roncal F, Albar JP, Marquez G, Bruix M, J Biol Chem. 2001 Jul 27;276(30):28372-9. Epub 2001 May 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373289 11373289]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Albar JP]]
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[[Category: Albar, J P.]]
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[[Category: Bruix M]]
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[[Category: Bruix, M.]]
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[[Category: Gutierrez J]]
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[[Category: Gutierrez, J.]]
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[[Category: Marquez G]]
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[[Category: Marquez, G.]]
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[[Category: Perez-Canadillas JM]]
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[[Category: Perez-Canadillas, J M.]]
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[[Category: Roncal F]]
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[[Category: Roncal, F.]]
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[[Category: Varona R]]
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[[Category: Varona, R.]]
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[[Category: Zaballos A]]
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[[Category: Zaballos, A.]]
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[[Category: ccl20/mip-3a]]
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[[Category: chemiokine]]
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[[Category: defensin]]
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[[Category: mouse]]
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[[Category: nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:34:24 2008''
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Current revision

NMR Solution Structure of Murine CCL20/MIP-3a Chemokine

PDB ID 1ha6

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