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1hfz

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{{Seed}}
 
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[[Image:1hfz.png|left|200px]]
 
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==ALPHA-LACTALBUMIN==
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The line below this paragraph, containing "STRUCTURE_1hfz", creates the "Structure Box" on the page.
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<StructureSection load='1hfz' size='340' side='right'caption='[[1hfz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hfz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HFZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HFZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_1hfz| PDB=1hfz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hfz OCA], [https://pdbe.org/1hfz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hfz RCSB], [https://www.ebi.ac.uk/pdbsum/1hfz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hfz ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LALBA_BOVIN LALBA_BOVIN] Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hf/1hfz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hfz ConSurf].
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<div style="clear:both"></div>
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===ALPHA-LACTALBUMIN===
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==See Also==
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*[[Alpha-lactalbumin 3D structures|Alpha-lactalbumin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8805552}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8805552 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8805552}}
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==About this Structure==
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1HFZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HFZ OCA].
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==Reference==
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Crystal structures of guinea-pig, goat and bovine alpha-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase., Pike AC, Brew K, Acharya KR, Structure. 1996 Jun 15;4(6):691-703. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8805552 8805552]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Lactose synthase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Acharya KR]]
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[[Category: Acharya, K R.]]
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[[Category: Brew K]]
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[[Category: Brew, K.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Calcium binding metalloprotein]]
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[[Category: Glycoprotein]]
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[[Category: Lactose]]
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[[Category: Lactose synthase component]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:08:01 2008''
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Current revision

ALPHA-LACTALBUMIN

PDB ID 1hfz

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