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1hly

From Proteopedia

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{{Seed}}
 
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[[Image:1hly.png|left|200px]]
 
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<!--
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==SOLUTION STRUCTURE OF HONGOTOXIN 1==
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The line below this paragraph, containing "STRUCTURE_1hly", creates the "Structure Box" on the page.
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<StructureSection load='1hly' size='340' side='right'caption='[[1hly]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hly]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_limbatus Centruroides limbatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HLY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hly OCA], [https://pdbe.org/1hly PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hly RCSB], [https://www.ebi.ac.uk/pdbsum/1hly PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hly ProSAT]</span></td></tr>
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{{STRUCTURE_1hly| PDB=1hly | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAX25_CENLM KAX25_CENLM] Potent selective inhibitor of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.3/KCNA3 voltage-gated potassium channels. Weak inhibitor of Kv1.6/KCNA6 potassium channel.<ref>PMID:9446567</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hl/1hly_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hly ConSurf].
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<div style="clear:both"></div>
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===SOLUTION STRUCTURE OF HONGOTOXIN 1===
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==See Also==
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*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_12009929}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12009929 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_12009929}}
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==About this Structure==
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1HLY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Centruroides_limbatus Centruroides limbatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HLY OCA].
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==Reference==
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Synthesis, characterization, and application of cy-dye- and alexa-dye-labeled hongotoxin(1) analogues. The first high affinity fluorescence probes for voltage-gated K+ channels., Pragl B, Koschak A, Trieb M, Obermair G, Kaufmann WA, Gerster U, Blanc E, Hahn C, Prinz H, Schutz G, Darbon H, Gruber HJ, Knaus HG, Bioconjug Chem. 2002 May-Jun;13(3):416-25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12009929 12009929]
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[[Category: Centruroides limbatus]]
[[Category: Centruroides limbatus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Blanc, E.]]
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[[Category: Blanc E]]
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[[Category: Darbon, H.]]
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[[Category: Darbon H]]
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[[Category: Gerster, U.]]
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[[Category: Gerster U]]
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[[Category: Gruber, H J.]]
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[[Category: Gruber HJ]]
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[[Category: Hahn, C.]]
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[[Category: Hahn C]]
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[[Category: Kaufmann, W A.]]
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[[Category: Kaufmann WA]]
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[[Category: Knaus, H G.]]
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[[Category: Knaus HG]]
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[[Category: Koschak, A.]]
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[[Category: Koschak A]]
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[[Category: Obermair, G.]]
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[[Category: Obermair G]]
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[[Category: Pragl, B.]]
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[[Category: Pragl B]]
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[[Category: Prinz, H.]]
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[[Category: Prinz H]]
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[[Category: Schutz, G.]]
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[[Category: Schutz G]]
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[[Category: Trieb, M.]]
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[[Category: Trieb M]]
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[[Category: Centruroides limbatus hgtx1]]
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[[Category: Potassium channel]]
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[[Category: Scorpion]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:22:35 2008''
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Current revision

SOLUTION STRUCTURE OF HONGOTOXIN 1

PDB ID 1hly

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