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1hm2

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{{Seed}}
 
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[[Image:1hm2.png|left|200px]]
 
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==ACTIVE SITE OF CHONDROITINASE AC LYASE REVEALED BY THE STRUCTURE OF ENZYME-OLIGOSACCHARIDE COMPLEXES AND MUTAGENESIS==
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The line below this paragraph, containing "STRUCTURE_1hm2", creates the "Structure Box" on the page.
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<StructureSection load='1hm2' size='340' side='right'caption='[[1hm2]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hm2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pedobacter_heparinus Pedobacter heparinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HM2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HM2 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ASG:2-DEOXY-2-ACETAMIDO-BETA-D-GALACTOSE-4-SULFATE'>ASG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GCU:D-GLUCURONIC+ACID'>GCU</scene>, <scene name='pdbligand=IDR:L-IDURONIC+ACID'>IDR</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MXY:2-O-METHYL+FUCOSE'>MXY</scene>, <scene name='pdbligand=RAM:ALPHA-L-RHAMNOSE'>RAM</scene>, <scene name='pdbligand=XYP:BETA-D-XYLOPYRANOSE'>XYP</scene></td></tr>
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{{STRUCTURE_1hm2| PDB=1hm2 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hm2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hm2 OCA], [https://pdbe.org/1hm2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hm2 RCSB], [https://www.ebi.ac.uk/pdbsum/1hm2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hm2 ProSAT]</span></td></tr>
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</table>
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===ACTIVE SITE OF CHONDROITINASE AC LYASE REVEALED BY THE STRUCTURE OF ENZYME-OLIGOSACCHARIDE COMPLEXES AND MUTAGENESIS===
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== Function ==
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[https://www.uniprot.org/uniprot/CSLA_PEDHD CSLA_PEDHD]
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== Evolutionary Conservation ==
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<!--
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_11327856}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 11327856 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hm/1hm2_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_11327856}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1HM2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pedobacter_heparinus Pedobacter heparinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HM2 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hm2 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis., Huang W, Boju L, Tkalec L, Su H, Yang HO, Gunay NS, Linhardt RJ, Kim YS, Matte A, Cygler M, Biochemistry. 2001 Feb 27;40(8):2359-72. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11327856 11327856]
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</StructureSection>
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[[Category: Chondroitin AC lyase]]
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[[Category: Large Structures]]
[[Category: Pedobacter heparinus]]
[[Category: Pedobacter heparinus]]
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[[Category: Single protein]]
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[[Category: Boju L]]
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[[Category: Boju, L.]]
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[[Category: Cygler M]]
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[[Category: Cygler, M.]]
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[[Category: Gunay NS]]
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[[Category: Gunay, N S.]]
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[[Category: Huang W]]
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[[Category: Huang, W.]]
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[[Category: Kim YS]]
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[[Category: Kim, Y S.]]
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[[Category: Linhardt RJ]]
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[[Category: Linhardt, R J.]]
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[[Category: Matte A]]
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[[Category: Matte, A.]]
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[[Category: Su H]]
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[[Category: Su, H.]]
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[[Category: Tkalec L]]
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[[Category: Tkalec, L.]]
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[[Category: Yang HO]]
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[[Category: Yang, H O.]]
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[[Category: Active site]]
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[[Category: Catalysis]]
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[[Category: Protein-oligosaccharide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:22:58 2008''
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Current revision

ACTIVE SITE OF CHONDROITINASE AC LYASE REVEALED BY THE STRUCTURE OF ENZYME-OLIGOSACCHARIDE COMPLEXES AND MUTAGENESIS

PDB ID 1hm2

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