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1hnf

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{{Seed}}
 
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[[Image:1hnf.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE HUMAN CELL ADHESION MOLECULE CD2 AT 2.5 ANGSTROMS RESOLUTION==
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The line below this paragraph, containing "STRUCTURE_1hnf", creates the "Structure Box" on the page.
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<StructureSection load='1hnf' size='340' side='right'caption='[[1hnf]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hnf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HNF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_1hnf| PDB=1hnf | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hnf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hnf OCA], [https://pdbe.org/1hnf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hnf RCSB], [https://www.ebi.ac.uk/pdbsum/1hnf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hnf ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD2_HUMAN CD2_HUMAN] CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/1hnf_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hnf ConSurf].
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<div style="clear:both"></div>
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===CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE HUMAN CELL ADHESION MOLECULE CD2 AT 2.5 ANGSTROMS RESOLUTION===
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==See Also==
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*[[CD2|CD2]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_7994575}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7994575 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7994575}}
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==About this Structure==
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1HNF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNF OCA].
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==Reference==
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Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution., Bodian DL, Jones EY, Harlos K, Stuart DI, Davis SJ, Structure. 1994 Aug 15;2(8):755-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7994575 7994575]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bodian, D L.]]
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[[Category: Bodian DL]]
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[[Category: Davis, S J.]]
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[[Category: Davis SJ]]
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[[Category: Harlos, K.]]
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[[Category: Harlos K]]
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[[Category: Jones, E Y.]]
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[[Category: Jones EY]]
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[[Category: Stuart, D I.]]
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[[Category: Stuart DI]]
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[[Category: T lymphocyte adhesion glycoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 08:26:01 2008''
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Current revision

CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE HUMAN CELL ADHESION MOLECULE CD2 AT 2.5 ANGSTROMS RESOLUTION

PDB ID 1hnf

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