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1hsm

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{{Seed}}
 
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[[Image:1hsm.png|left|200px]]
 
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==THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA==
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The line below this paragraph, containing "STRUCTURE_1hsm", creates the "Structure Box" on the page.
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<StructureSection load='1hsm' size='340' side='right'caption='[[1hsm]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HSM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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-->
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene></td></tr>
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{{STRUCTURE_1hsm| PDB=1hsm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hsm OCA], [https://pdbe.org/1hsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hsm RCSB], [https://www.ebi.ac.uk/pdbsum/1hsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hsm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HMGB1_CRIGR HMGB1_CRIGR] DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/1hsm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hsm ConSurf].
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<div style="clear:both"></div>
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===THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA===
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==See Also==
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*[[High mobility group protein|High mobility group protein]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1HSM is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HSM OCA].
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[[Category: Cricetulus griseus]]
[[Category: Cricetulus griseus]]
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[[Category: Carillo, M O.M.]]
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[[Category: Large Structures]]
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[[Category: Cary, P D.]]
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[[Category: Carillo MOM]]
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[[Category: Crane-Robinson, C.]]
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[[Category: Cary PD]]
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[[Category: Driscoll, P C.]]
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[[Category: Crane-Robinson C]]
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[[Category: Norman, D G.]]
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[[Category: Driscoll PC]]
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[[Category: Read, C M.]]
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[[Category: Norman DG]]
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[[Category: Dna-binding]]
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[[Category: Read CM]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 19:47:41 2009''
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Current revision

THE STRUCTURE OF THE HMG BOX AND ITS INTERACTION WITH DNA

PDB ID 1hsm

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