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1hu3

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[[Image:1hu3.gif|left|200px]]
 
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{{Structure
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==MIDDLE DOMAIN OF HUMAN EIF4GII==
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|PDB= 1hu3 |SIZE=350|CAPTION= <scene name='initialview01'>1hu3</scene>, resolution 2.37&Aring;
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<StructureSection load='1hu3' size='340' side='right'caption='[[1hu3]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1hu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HU3 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hu3 OCA], [https://pdbe.org/1hu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hu3 RCSB], [https://www.ebi.ac.uk/pdbsum/1hu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hu3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IF4G3_HUMAN IF4G3_HUMAN] Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1.<ref>PMID:9418880</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hu/1hu3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hu3 ConSurf].
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<div style="clear:both"></div>
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'''MIDDLE DOMAIN OF HUMAN EIF4GII'''
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
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== References ==
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==Overview==
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<references/>
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The X-ray structure of the phylogenetically conserved middle portion of human eukaryotic initiation factor (eIF) 4GII has been determined at 2.4 A resolution, revealing a crescent-shaped domain consisting of ten alpha helices arranged as five HEAT repeats. Together with the ATP-dependent RNA helicase eIF4A, this HEAT domain suffices for 48S ribosomal complex formation with a picornaviral RNA internal ribosome entry site (IRES). Structure-based site-directed mutagenesis was used to identify two adjacent features on the surface of this essential component of the translation initiation machinery that, respectively, bind eIF4A and a picornaviral IRES. The structural and biochemical results provide mechanistic insights into both cap-dependent and cap-independent translation initiation.
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__TOC__
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</StructureSection>
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==About this Structure==
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1HU3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HU3 OCA].
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==Reference==
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A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery., Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK, Mol Cell. 2001 Jan;7(1):193-203. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11172724 11172724]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Hellen, C U.T.]]
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[[Category: Hellen CUT]]
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[[Category: Lomakin, I.]]
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[[Category: Lomakin I]]
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[[Category: Marcotrigiano, J.]]
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[[Category: Marcotrigiano J]]
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[[Category: Pestova, T V.]]
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[[Category: Pestova TV]]
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[[Category: Sonenberg, N.]]
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[[Category: Sonenberg N]]
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[[Category: eif4g]]
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[[Category: heat repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 11:41:34 2008''
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Current revision

MIDDLE DOMAIN OF HUMAN EIF4GII

PDB ID 1hu3

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