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1hxm

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{{Seed}}
 
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[[Image:1hxm.png|left|200px]]
 
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==Crystal Structure of a Human Vgamma9/Vdelta2 T Cell Receptor==
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The line below this paragraph, containing "STRUCTURE_1hxm", creates the "Structure Box" on the page.
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<StructureSection load='1hxm' size='340' side='right'caption='[[1hxm]], [[Resolution|resolution]] 3.12&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1hxm]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HXM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.12&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1hxm| PDB=1hxm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hxm OCA], [https://pdbe.org/1hxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hxm RCSB], [https://www.ebi.ac.uk/pdbsum/1hxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hxm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRDC_HUMAN TRDC_HUMAN] Constant region of T cell receptor (TR) delta chain that participates in the antigen recognition (PubMed:24600447). Gamma-delta TRs recognize a variety of self and foreign non-peptide antigens frequently expressed at the epithelial boundaries between the host and external environment, including endogenous lipids presented by MH-like protein CD1D and phosphoantigens presented by butyrophilin-like molecule BTN3A1. Upon antigen recognition induces rapid, innate-like immune responses involved in pathogen clearance and tissue repair (PubMed:28920588, PubMed:23348415). Binding of gamma-delta TR complex to antigen triggers phosphorylation of immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains by the LCK and FYN kinases, allowing the recruitment, phosphorylation, and activation of ZAP70 that facilitates phosphorylation of the scaffolding proteins LCP2 and LAT. This lead to the formation of a supramolecular signalosome that recruits the phospholipase PLCG1, resulting in calcium mobilization and ERK activation, ultimately leading to T cell expansion and differentiation into effector cells (PubMed:25674089). Gamma-delta TRs are produced through somatic rearrangement of a limited repertoire of variable (V), diversity (D), and joining (J) genes. The potential diversity of gamma-delta TRs is conferred by the unique ability to rearrange (D) genes in tandem and to utilize all three reading frames. The combinatorial diversity is considerably increased by the sequence exonuclease trimming and random nucleotide (N) region additions which occur during the V-(D)-J rearrangements (PubMed:24387714).<ref>PMID:23348415</ref> <ref>PMID:24387714</ref> <ref>PMID:24600447</ref> <ref>PMID:25674089</ref> <ref>PMID:28920588</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hx/1hxm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hxm ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of a Human Vgamma9/Vdelta2 T Cell Receptor===
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==See Also==
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*[[T-cell receptor 3D structures|T-cell receptor 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_11459064}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 11459064 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_11459064}}
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==About this Structure==
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1HXM is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HXM OCA].
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==Reference==
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<ref group="xtra">PMID:11459064</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Allison, T J.]]
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[[Category: Large Structures]]
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[[Category: Bonneville, M.]]
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[[Category: Allison TJ]]
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[[Category: Fournie, J J.]]
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[[Category: Bonneville M]]
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[[Category: Garboczi, D N.]]
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[[Category: Fournie JJ]]
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[[Category: Winter, C C.]]
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[[Category: Garboczi DN]]
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[[Category: Gdtcr]]
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[[Category: Winter CC]]
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[[Category: Ig domain]]
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[[Category: T cell receptor]]
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[[Category: Tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:16:06 2009''
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Current revision

Crystal Structure of a Human Vgamma9/Vdelta2 T Cell Receptor

PDB ID 1hxm

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