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8j6i
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8j6i is ON HOLD Authors: Yuan, Q., Zhu, S., Duan, J., Xu, H.E., Duan, X. Description: Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892== | |
| - | + | <StructureSection load='8j6i' size='340' side='right'caption='[[8j6i]], [[Resolution|resolution]] 2.92Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8j6i]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J6I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.92Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FI7:2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic+acid'>FI7</scene></td></tr> |
| - | [[Category: Duan | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j6i OCA], [https://pdbe.org/8j6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j6i RCSB], [https://www.ebi.ac.uk/pdbsum/8j6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j6i ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Yuan | + | [https://www.uniprot.org/uniprot/HCAR2_HUMAN HCAR2_HUMAN] Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.<ref>PMID:17932499</ref> |
| - | [[Category: Zhu | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Duan J]] | ||
| + | [[Category: Duan X]] | ||
| + | [[Category: Xu HE]] | ||
| + | [[Category: Yuan Q]] | ||
| + | [[Category: Zhu S]] | ||
Current revision
Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892
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Categories: Homo sapiens | Large Structures | Duan J | Duan X | Xu HE | Yuan Q | Zhu S
