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8jfk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8jfk is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==PhK holoenzyme in inactive state, muscle isoform== | |
| - | + | <StructureSection load='8jfk' size='340' side='right'caption='[[8jfk]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8jfk]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JFK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAR:FARNESYL'>FAR</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jfk OCA], [https://pdbe.org/8jfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jfk RCSB], [https://www.ebi.ac.uk/pdbsum/8jfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jfk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/KPBB_HUMAN KPBB_HUMAN] Glycogen storage disease due to liver and muscle phosphorylase kinase deficiency. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/KPBB_HUMAN KPBB_HUMAN] Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Xiao JY]] | ||
| + | [[Category: Yang XK]] | ||
Current revision
PhK holoenzyme in inactive state, muscle isoform
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