This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
8oi2
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8oi2 is ON HOLD Authors: De Felice, S., Zoia, G., Romanyuk, Z., Pardon, E., Steyaert, J., Angelini, A., Cendron, L. Description: Crystal structure ...) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Alb1 megabody in complex with human serum albumin== | |
| - | + | <StructureSection load='8oi2' size='340' side='right'caption='[[8oi2]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8oi2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_G27 Helicobacter pylori G27] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OI2 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oi2 OCA], [https://pdbe.org/8oi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oi2 RCSB], [https://www.ebi.ac.uk/pdbsum/8oi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oi2 ProSAT]</span></td></tr> |
| - | [[Category: Angelini | + | </table> |
| - | [[Category: | + | == Disease == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: Zoia | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Helicobacter pylori G27]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Angelini A]] | ||
| + | [[Category: Cendron L]] | ||
| + | [[Category: De Felice S]] | ||
| + | [[Category: Pardon E]] | ||
| + | [[Category: Romanyuk Z]] | ||
| + | [[Category: Steyaert J]] | ||
| + | [[Category: Zoia G]] | ||
Current revision
Crystal structure of Alb1 megabody in complex with human serum albumin
| |||||||||||
