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8sl3

From Proteopedia

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'''Unreleased structure'''
 
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The entry 8sl3 is ON HOLD
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==Human adenylyl Cyclase 5 in complex with Gbg==
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<StructureSection load='8sl3' size='340' side='right'caption='[[8sl3]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8sl3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SL3 FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GER:GERAN-8-YL+GERAN'>GER</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sl3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sl3 OCA], [https://pdbe.org/8sl3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sl3 RCSB], [https://www.ebi.ac.uk/pdbsum/8sl3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sl3 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ADCY5_HUMAN ADCY5_HUMAN] Familial dyskinesia and facial myokymia;Benign hereditary chorea. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/ADCY5_HUMAN ADCY5_HUMAN] Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569).<ref>PMID:15385642</ref> <ref>PMID:24700542</ref> <ref>PMID:24740569</ref> <ref>PMID:26206488</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Tesmer JJG]]
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[[Category: Yen YC]]

Current revision

Human adenylyl Cyclase 5 in complex with Gbg

PDB ID 8sl3

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