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8slo

From Proteopedia

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m (Protected "8slo" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8slo is ON HOLD
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==Plasmodium falciparum M1 aminopeptidase bound to selective inhibitor MIPS2673==
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<StructureSection load='8slo' size='340' side='right'caption='[[8slo]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8slo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SLO FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BYW:2-hydroxy-N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3,4,5-trifluoro[1,1-biphenyl]-4-yl)ethyl]-2-methylpropanamide'>BYW</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8slo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8slo OCA], [https://pdbe.org/8slo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8slo RCSB], [https://www.ebi.ac.uk/pdbsum/8slo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8slo ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMPN_PLAF7 AMPN_PLAF7] Displays aminopeptidase activity with a broad substrate specificity (PubMed:9879894, PubMed:12166515, PubMed:21659511, PubMed:22359643, PubMed:34133730, PubMed:33536500, PubMed:19196988, PubMed:21844374, PubMed:23897806). Preferentially, cleaves after Leu and Met, but cleaves also after Ala and Arg (PubMed:12166515, PubMed:22359643, PubMed:33536500, PubMed:21844374). Low activity towards Lys, Phe, Tyr, Trp, Gln, Ser and Gly and negligible activity towards Glu, Asp, Pro, Ile, Thr, Val, His and Asn (PubMed:22359643). Has dipeptidase activity (PubMed:21659511, PubMed:23897806). Plays a role in the terminal stages of host hemoglobin digestion by cleaving the N-terminal residue of small hemoglobin-derived oligopeptides (PubMed:21659511, PubMed:34133730, PubMed:21844374).<ref>PMID:12166515</ref> <ref>PMID:19196988</ref> <ref>PMID:21659511</ref> <ref>PMID:21844374</ref> <ref>PMID:22359643</ref> <ref>PMID:23897806</ref> <ref>PMID:33536500</ref> <ref>PMID:34133730</ref> <ref>PMID:9879894</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum]]
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[[Category: Drinkwater N]]
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[[Category: McGowan SM]]

Current revision

Plasmodium falciparum M1 aminopeptidase bound to selective inhibitor MIPS2673

PDB ID 8slo

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