This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ah0

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:54, 3 April 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1ah0.png|left|200px]]
 
-
<!--
+
==PIG ALDOSE REDUCTASE COMPLEXED WITH SORBINIL==
-
The line below this paragraph, containing "STRUCTURE_1ah0", creates the "Structure Box" on the page.
+
<StructureSection load='1ah0' size='340' side='right'caption='[[1ah0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1ah0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AH0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AH0 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SBI:SORBINIL'>SBI</scene></td></tr>
-
{{STRUCTURE_1ah0| PDB=1ah0 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ah0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ah0 OCA], [https://pdbe.org/1ah0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ah0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ah0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ah0 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ALDR_PIG ALDR_PIG] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1ah0_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ah0 ConSurf].
 +
<div style="clear:both"></div>
-
===PIG ALDOSE REDUCTASE COMPLEXED WITH SORBINIL===
+
==See Also==
-
 
+
*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_9195881}}, adds the Publication Abstract to the page
+
[[Category: Large Structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 9195881 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_9195881}}
+
-
 
+
-
==About this Structure==
+
-
1AH0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AH0 OCA].
+
-
 
+
-
==Reference==
+
-
A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil., Urzhumtsev A, Tete-Favier F, Mitschler A, Barbanton J, Barth P, Urzhumtseva L, Biellmann JF, Podjarny A, Moras D, Structure. 1997 May 15;5(5):601-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9195881 9195881]
+
-
[[Category: Aldehyde reductase]]
+
-
[[Category: Single protein]]
+
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
-
[[Category: Moras, D.]]
+
[[Category: Moras D]]
-
[[Category: Podjarny, A D.]]
+
[[Category: Podjarny AD]]
-
[[Category: Diabetes]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Sorbinil inhibitor]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:49:44 2008''
+

Current revision

PIG ALDOSE REDUCTASE COMPLEXED WITH SORBINIL

PDB ID 1ah0

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ah0"
Personal tools