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1ah3

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{{Seed}}
 
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[[Image:1ah3.png|left|200px]]
 
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==ALDOSE REDUCTASE COMPLEXED WITH TOLRESTAT INHIBITOR==
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The line below this paragraph, containing "STRUCTURE_1ah3", creates the "Structure Box" on the page.
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<StructureSection load='1ah3' size='340' side='right'caption='[[1ah3]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ah3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AH3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYA:N-ACETYLALANINE'>AYA</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=TOL:TOLRESTAT'>TOL</scene></td></tr>
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{{STRUCTURE_1ah3| PDB=1ah3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ah3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ah3 OCA], [https://pdbe.org/1ah3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ah3 RCSB], [https://www.ebi.ac.uk/pdbsum/1ah3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ah3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALDR_PIG ALDR_PIG] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ah/1ah3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ah3 ConSurf].
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<div style="clear:both"></div>
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===ALDOSE REDUCTASE COMPLEXED WITH TOLRESTAT INHIBITOR===
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==See Also==
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*[[Aldose reductase 3D structures|Aldose reductase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_9195881}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9195881 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9195881}}
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==About this Structure==
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1AH3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AH3 OCA].
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==Reference==
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A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil., Urzhumtsev A, Tete-Favier F, Mitschler A, Barbanton J, Barth P, Urzhumtseva L, Biellmann JF, Podjarny A, Moras D, Structure. 1997 May 15;5(5):601-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9195881 9195881]
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[[Category: Aldehyde reductase]]
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[[Category: Single protein]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Moras, D.]]
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[[Category: Moras D]]
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[[Category: Podjarny, A.]]
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[[Category: Podjarny A]]
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[[Category: Aldose reductase]]
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[[Category: Diabetes]]
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[[Category: Inhibition]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 16:50:14 2008''
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Current revision

ALDOSE REDUCTASE COMPLEXED WITH TOLRESTAT INHIBITOR

PDB ID 1ah3

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