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1b1z

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(New page: 200px<br /><applet load="1b1z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b1z, resolution 2.57&Aring;" /> '''STREPTOCOCCAL PYROGE...)
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[[Image:1b1z.gif|left|200px]]<br /><applet load="1b1z" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1b1z, resolution 2.57&Aring;" />
 
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'''STREPTOCOCCAL PYROGENIC EXOTOXIN A1'''<br />
 
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==Overview==
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==STREPTOCOCCAL PYROGENIC EXOTOXIN A1==
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Streptococcal pyrogenic exotoxin A (SpeA) is a superantigen produced by, Streptococcus pyogenes and is associated with severe infections, characterized by rash, hypotension, multiorgan failure and a high, mortality rate. In this study, an allelic form of this toxin, SpeA1, was, crystallized with four molecules in the crystallographic asymmetric unit, and its crystal structure was determined at 2.6 A resolution. The, crystallographic R-factor was 19.4% (33 497 reflections) for 7031 protein, atoms and 88 water molecules. The overall structure of SpeA1 is, considerably similar to that of other prototype microbial superantigens, either of staphylococcal or streptococcal origin, but has greatest, similarity to staphylococcal enterotoxin C (SEC). Based on structural and, mutagenesis data, we have mapped several important residues on the toxin, molecule, which are involved in the recognition of major, histocompatibility complex (MHC) class II molecules and T-cell receptors., Also, the toxin appears to possess a potential zinc-binding site which may, have implications in binding to particular MHC class II molecules., Finally, we propose models for SpeA1-MHC class II and SpeA1-T-cell, receptor association and the relevance of this phenomenon to the, superantigenic action of this toxin is considered.
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<StructureSection load='1b1z' size='340' side='right'caption='[[1b1z]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1b1z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B1Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.57&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b1z OCA], [https://pdbe.org/1b1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b1z RCSB], [https://www.ebi.ac.uk/pdbsum/1b1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b1z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPEA_STRPY SPEA_STRPY] Causative agent of the symptoms associated with scarlet fever, have been associated with streptococcal toxic shock-like disease and may play a role in the early events of rheumatic fever.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b1/1b1z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b1z ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1B1Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B1Z OCA].
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*[[Exotoxin 3D structures|Exotoxin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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Structural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T-cell receptors., Papageorgiou AC, Collins CM, Gutman DM, Kline JB, O'Brien SM, Tranter HS, Acharya KR, EMBO J. 1999 Jan 4;18(1):9-21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9878045 9878045]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
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[[Category: Acharya, K.R.]]
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[[Category: Acharya KR]]
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[[Category: Papageorgiou, A.C.]]
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[[Category: Papageorgiou AC]]
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[[Category: pyrogenic exotoxin]]
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[[Category: superantigen]]
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[[Category: zinc binding]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:17:13 2007''
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Current revision

STREPTOCOCCAL PYROGENIC EXOTOXIN A1

PDB ID 1b1z

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