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1b7z

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(New page: 200px<br /><applet load="1b7z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b7z, resolution 2.7&Aring;" /> '''STRUCTURE OF OXALATE ...)
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[[Image:1b7z.jpg|left|200px]]<br /><applet load="1b7z" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1b7z, resolution 2.7&Aring;" />
 
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'''STRUCTURE OF OXALATE SUBSTITUTED DIFERRIC MARE LACTOFERRIN FROM COLOSTRUM'''<br />
 
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==Overview==
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==STRUCTURE OF OXALATE SUBSTITUTED DIFERRIC MARE LACTOFERRIN FROM COLOSTRUM==
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Lactoferrin binds two Fe(3+) and two CO(2-)(3) ions with high affinity. It, can also bind other metal ions and anions. In order to determine the, perturbations in the environments of the binding sites in the N and C, lobes and elsewhere in the protein, the crystal structure of, oxalate-substituted diferric mare lactoferrin has been determined at 2.7 A, resolution. The final model has a crystallographic R factor of 21.3% for, all data in the resolution range 17.0-2.7 A. The substitution of an, oxalate anion does not perturb the overall structure of the protein, but, produces several significant changes at the metal-binding and, anion-binding sites. The binding of the oxalate anion is symmetrical in, both the N and C lobes, unlike in diferric dioxalate human lactoferrin, where the oxalate anion binds the metal ion symmetrically in the C lobe, and asymmetrically in the N lobe.
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<StructureSection load='1b7z' size='340' side='right'caption='[[1b7z]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1b7z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B7Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=OXL:OXALATE+ION'>OXL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b7z OCA], [https://pdbe.org/1b7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b7z RCSB], [https://www.ebi.ac.uk/pdbsum/1b7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b7z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRFL_HORSE TRFL_HORSE] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/1b7z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b7z ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1B7Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus] with FE and OXL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B7Z OCA].
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*[[Lactoferrin|Lactoferrin]]
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__TOC__
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==Reference==
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</StructureSection>
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Structure of oxalate-substituted diferric mare lactoferrin at 2.7 A resolution., Sharma AK, Singh TP, Acta Crystallogr D Biol Crystallogr. 1999 Nov;55(Pt 11):1792-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10531474 10531474]
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[[Category: Equus caballus]]
[[Category: Equus caballus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Sharma, A.K.]]
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[[Category: Sharma AK]]
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[[Category: Singh, T.P.]]
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[[Category: Singh TP]]
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[[Category: FE]]
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[[Category: OXL]]
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[[Category: dioxalate]]
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[[Category: lactoferrin]]
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[[Category: metal binding site]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:26:25 2007''
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Current revision

STRUCTURE OF OXALATE SUBSTITUTED DIFERRIC MARE LACTOFERRIN FROM COLOSTRUM

PDB ID 1b7z

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