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1b98

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[[Image:1b98.png|left|200px]]
 
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{{STRUCTURE_1b98| PDB=1b98 | SCENE= }}
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==NEUROTROPHIN 4 (HOMODIMER)==
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<StructureSection load='1b98' size='340' side='right'caption='[[1b98]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1b98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2005 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Neurotrophins'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2005_8 10.2210/rcsb_pdb/mom_2005_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B98 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b98 OCA], [https://pdbe.org/1b98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b98 RCSB], [https://www.ebi.ac.uk/pdbsum/1b98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b98 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN] Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O) [MIM:[https://omim.org/entry/613100 613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
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== Function ==
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[https://www.uniprot.org/uniprot/NTF4_HUMAN NTF4_HUMAN] Target-derived survival factor for peripheral sensory sympathetic neurons.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/1b98_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1b98 ConSurf].
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<div style="clear:both"></div>
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===NEUROTROPHIN 4 (HOMODIMER)===
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==See Also==
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*[[Neurotrophin|Neurotrophin]]
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{{ABSTRACT_PUBMED_10631974}}
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*[[Neutrotrophin|Neutrotrophin]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[1b98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2005 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Neurotrophins'' by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2005_8 10.2210/rcsb_pdb/mom_2005_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B98 OCA].
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==Reference==
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<ref group="xtra">PMID:010631974</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Neurotrophins]]
[[Category: Neurotrophins]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Choe, S.]]
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[[Category: Choe S]]
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[[Category: Jones, E Y.]]
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[[Category: Jones EY]]
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[[Category: Radziejewski, C.]]
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[[Category: Radziejewski C]]
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[[Category: Robinson, R C.]]
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[[Category: Robinson RC]]
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[[Category: Stuart, D I.]]
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[[Category: Stuart DI]]
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[[Category: Hormone-growth factor complex]]
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[[Category: Neurotrophin 4]]
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[[Category: Neurotrophin 5]]
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[[Category: Target-derived survival factor]]
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Current revision

NEUROTROPHIN 4 (HOMODIMER)

PDB ID 1b98

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