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1cic

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[[Image:1cic.jpg|left|200px]]
 
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{{Structure
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==IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225==
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|PDB= 1cic |SIZE=350|CAPTION= <scene name='initialview01'>1cic</scene>, resolution 2.5&Aring;
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<StructureSection load='1cic' size='340' side='right'caption='[[1cic]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1cic]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CIC FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cic OCA], [https://pdbe.org/1cic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cic RCSB], [https://www.ebi.ac.uk/pdbsum/1cic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cic ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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'''IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225'''
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[https://www.uniprot.org/uniprot/IGKC_MOUSE IGKC_MOUSE]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==Overview==
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Check<jmol>
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Serologically detected antigenic determinants unique to an antibody or group of antibodies are called idiotopes. The sum of idiotopes of an antibody constitute its idiotype. Idiotypes have been intensively studied following a hypothesis for the self-regulation of the immune system through a network of idiotype-anti-idiotype interactions. Furthermore, as antigen and anti-idiotypes can competitively bind to idiotype-positive, antigen-specific antibodies, anti-idiotypes may carry an 'internal image' of the external antigen. Here we describe the structure of the complex between the monoclonal anti-lysozyme FabD1.3 and the anti-idiotopic FabE225 at 2.5 A resolution. This complex defines a private idiotope consisting of 13 amino-acid residues, mainly from the complementarity-determining regions of D1.3. Seven of these residues make contacts with the antigen, indicating a significant overlap between idiotope and antigen-combining site. Idiotopic mimicry of the external antigen is not achieved at the molecular level in this example.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/1cic_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1CIC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CIC OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cic ConSurf].
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Three-dimensional structure of an idiotope-anti-idiotope complex., Bentley GA, Boulot G, Riottot MM, Poljak RJ, Nature. 1990 Nov 15;348(6298):254-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1700305 1700305]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Bentley GA]]
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[[Category: Bentley, G A.]]
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[[Category: anti-idiotope]]
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[[Category: fab complex]]
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[[Category: idiotope]]
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[[Category: immunoglobulin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:24:44 2008''
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Current revision

IDIOTOPE-ANTI-IDIOTOPE FAB-FAB COMPLEX; D1.3-E225

PDB ID 1cic

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