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1coi

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[[Image:1coi.jpg|left|200px]]
 
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==DESIGNED TRIMERIC COILED COIL-VALD==
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The line below this paragraph, containing "STRUCTURE_1coi", creates the "Structure Box" on the page.
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<StructureSection load='1coi' size='340' side='right'caption='[[1coi]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1coi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1coi| PDB=1coi | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1coi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coi OCA], [https://pdbe.org/1coi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1coi RCSB], [https://www.ebi.ac.uk/pdbsum/1coi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1coi ProSAT]</span></td></tr>
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</table>
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'''DESIGNED TRIMERIC COILED COIL-VALD'''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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==Overview==
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[[Category: Synthetic construct]]
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The three-dimensional structure of the 29-residue designed coiled coil having the amino acid sequence acetyl-E VEALEKK VAALESK VQALEKK VEALEHG-amide has been determined and refined to a crystallographic R-factor of 21.4% for all data from 10-A to 2.1-A resolution. This molecule is called coil-VaLd because it contains valine in the a heptad positions and leucine in the d heptad positions. In the trigonal crystal, three molecules, related by a crystallographic threefold axis, form a parallel three-helix bundle. The bundles are stacked head-to-tail to form a continuous coiled coil along the c-direction of the crystal. The contacts among the three helices within the coiled coil are mainly hydrophobic: four layers of valine residues alternate with four layers of leucine residues to form the core of the bundle. In contrast, mostly hydrophilic contacts mediate the interaction between trimers: here a total of two direct protein--protein hydrogen bonds are found. Based on the structure, we propose a scheme for designing crystals of peptides containing continuous two-, three-, and four-stranded coiled coils.
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[[Category: Degrado WF]]
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[[Category: Eisenberg D]]
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==About this Structure==
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[[Category: Ogihara NL]]
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COI OCA].
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[[Category: Weiss MS]]
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==Reference==
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The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies., Ogihara NL, Weiss MS, Degrado WF, Eisenberg D, Protein Sci. 1997 Jan;6(1):80-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9007979 9007979]
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[[Category: Degrado, W F.]]
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[[Category: Eisenberg, D.]]
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[[Category: Ogihara, N L.]]
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[[Category: Weiss, M S.]]
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[[Category: Alpha-helical bundle]]
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[[Category: Coiled coil design]]
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[[Category: Protein design]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:56:57 2008''
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Current revision

DESIGNED TRIMERIC COILED COIL-VALD

PDB ID 1coi

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