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1gmk

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[[Image:1gmk.gif|left|200px]]<br />
 
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<applet load="1gmk" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1gmk, resolution 2.5&Aring;" />
 
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'''GRAMICIDIN/KSCN COMPLEX'''<br />
 
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==Overview==
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==GRAMICIDIN/KSCN COMPLEX==
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The hydrophobic channel-forming polypeptide gramicidin adopts a, left-handed antiparallel double helix conformation with 6.4 residues per, turn when in complex with monovalent cation salts in a methanol, environment. The crystal structure of the gramicidin/potassium thiocyanate, complex (a = 32.06 A, b = 51.80 A, and c = 31.04 A; space group, P2(1)2(1)2(1)) has been solved to 2.5 A with an R-factor of 0.193. In the, structure, binding sites for the cations are formed by the polypeptide, backbone carbonyl groups tilting away from the helix axis toward the ions, located in the central lumen. The polypeptide backbone conformations and, the side-chain orientations in this potassium complex are significantly, different from those in the previously solved gramicidin/caesium chloride, crystal ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9086274 (full description)]]
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<StructureSection load='1gmk' size='340' side='right'caption='[[1gmk]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1gmk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GMK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GMK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=FVA:N-FORMYL-L-VALINE'>FVA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=PRD_000150:GRAMICIDIN+A'>PRD_000150</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gmk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gmk OCA], [https://pdbe.org/1gmk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gmk RCSB], [https://www.ebi.ac.uk/pdbsum/1gmk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gmk ProSAT]</span></td></tr>
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</table>
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==About this Structure==
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==See Also==
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1GMK is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]] with K, SCN, FOR and MOH as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: K2 and K4. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GMK OCA]].
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*[[Gramicidin|Gramicidin]]
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of the gramicidin/potassium thiocyanate complex., Doyle DA, Wallace BA, J Mol Biol. 1997 Mar 14;266(5):963-77. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9086274 9086274]
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[[Category: Brevibacillus brevis]]
[[Category: Brevibacillus brevis]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Doyle, D.A.]]
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[[Category: Doyle DA]]
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[[Category: Wallace, B.A.]]
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[[Category: Wallace BA]]
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[[Category: FOR]]
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[[Category: K]]
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[[Category: MOH]]
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[[Category: SCN]]
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[[Category: membrane ion channel]]
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[[Category: peptide antibiotic]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 15:15:11 2007''
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Current revision

GRAMICIDIN/KSCN COMPLEX

PDB ID 1gmk

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